Dynactin 4 antibody (AA 57-298)

Catalog No. ABIN1724791

Product Details anti-Dynactin 4 Antibody

Target: Dynactin 4 (DCTN4)

Binding Specificity: AA 57-298

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Dynactin 4 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunocytochemistry (ICC)

Purpose: DCTN4 Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human DCTN4 (AA: 57-298) expressed in E. Coli.

Clone: 3G9D7

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-Dynactin 4 antibody (ABIN1724791)

Ayalon, Davis, Scotland, Bennett: "An ankyrin-based mechanism for functional organization of dystrophin and dystroglycan." in: Cell, Vol. 135, Issue 7, pp. 1189-200, (2008) (PubMed).

Lim, Cater, Mercer, La Fontaine: "Copper-dependent interaction of dynactin subunit p62 with the N terminus of ATP7B but not ATP7A." in: The Journal of biological chemistry, Vol. 281, Issue 20, pp. 14006-14, (2006) (PubMed).

Target Details for Dynactin 4

Target: Dynactin 4 (DCTN4)

Alternative Name: DCTN4 (DCTN4 Products)

Synonyms: DYN4 antibody, P62 antibody, MGC84654 antibody, zgc:112431 antibody, MGC97564 antibody, 1110001K06Rik antibody, 4930547K17Rik antibody, C130039E17Rik antibody, p62 antibody, dynactin subunit 4 antibody, dynactin subunit 4 L homeolog antibody, dynactin 4 antibody, dynactin 4, putative antibody, DCTN4 antibody, Dctn4 antibody, dctn4.L antibody, dctn4 antibody, PKH_031720 antibody

Background:

Description: Dynactin 4 could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton.The dynactin complex binds cargo, such as vesicles and organelles, to cytoplasmic dynein for retrograde microtubule-mediated trafficking and could feasibly be involved in the copper-regulated trafficking of ATP7B.

Aliases: P62, DYN4

Molecular Weight: 52.3kDa

Gene ID: 51164

HGNC: 51164

UniProt: Q9UJW0