GUCY1A1 antibody (AA 22-214)

Catalog No. ABIN1724787

Product Details anti-GUCY1A1 Antibody

Target: GUCY1A1 (Guanylate Cyclase 1 Soluble Subunit Alpha (GUCY1A1))

Binding Specificity: AA 22-214

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This GUCY1A1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunocytochemistry (ICC)

Purpose: GUCY1A3 Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human GUCY1A3 (AA: 22-214) expressed in E. Coli.

Clone: 3G6B2

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-GUCY1A1 antibody (ABIN1724787)

Cai, Hsieh, Gao, Kannan, Bhansali, Govardhan, Dutta, Shemshedini: "Soluble guanylyl cyclase ?1 and p53 cytoplasmic sequestration and down-regulation in prostate cancer." in: Molecular endocrinology (Baltimore, Md.), Vol. 26, Issue 2, pp. 292-307, (2012) (PubMed).

Zhong, Pan, Liu, Wang, Ying, Su, Huang, Tan: "A novel insight into the heme and NO/CO binding mechanism of the alpha subunit of human soluble guanylate cyclase." in: Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, Vol. 16, Issue 8, pp. 1227-39, (2011) (PubMed).

Target Details for GUCY1A1

Target: GUCY1A1 (Guanylate Cyclase 1 Soluble Subunit Alpha (GUCY1A1))

Alternative Name: GUCY1A3 (GUCY1A1 Products)

Synonyms: GC-SA3 antibody, GUC1A3 antibody, GUCA3 antibody, GUCSA3 antibody, GUCY1A1 antibody, 1200016O07Rik antibody, Gucy1a1 antibody, SGC antibody, im:7136149 antibody, sgc1a1 antibody, zgc:112159 antibody, gucy1a3 antibody, guanylate cyclase 1 soluble subunit alpha antibody, guanylate cyclase 1, soluble, alpha 3 antibody, guanylate cyclase 1 soluble subunit alpha 3 antibody, soluble guanylyl cyclase alpha subunit antibody, GUCY1A3 antibody, Gucy1a3 antibody, gucy1a3 antibody

Background:

Description: Soluble guanylate cyclases are heterodimeric proteins that catalyze the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. The protein encoded by this gene is an alpha subunit of this complex and it interacts with a beta subunit to form the guanylate cyclase enzyme, which is activated by nitric oxide. Several transcript variants encoding a few different isoforms have been found for this gene.

Aliases: GUCA3, GC-SA3, GUC1A3, GUCSA3, GUCY1A1

Molecular Weight: 77.5kDa

Gene ID: 2982

HGNC: 2982

Pathways: Myometrial Relaxation and Contraction