PDE1B antibody (AA 370-536)

Catalog No. ABIN1724781

Product Details anti-PDE1B Antibody

Target: PDE1B (phosphodiesterase 1B, Calmodulin-Dependent (PDE1B))

Binding Specificity: AA 370-536

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PDE1B antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)

Purification: purified

Immunogen: Purified recombinant fragment of human PDE1B (AA: 370-536 ) expressed in E. coli.

Clone: 5C4A3

Isotype: IgG1

Application Details

Application Notes: ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000, FCM: 1:200 - 1:400

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: 4°C, -20°C for long term storage

References for anti-PDE1B antibody (ABIN1724781)

Vandeput, Wolda, Krall, Hambleton, Uher, McCaw, Radwanski, Florio, Movsesian: "Cyclic nucleotide phosphodiesterase PDE1C1 in human cardiac myocytes." in: The Journal of biological chemistry, Vol. 282, Issue 45, pp. 32749-57, (2007) (PubMed).

Target Details for PDE1B

Target: PDE1B (phosphodiesterase 1B, Calmodulin-Dependent (PDE1B))

Alternative Name: PDE1B (PDE1B Products)

Synonyms: 63kDa antibody, Pde1b1 antibody, PDE1B1 antibody, PDES1B antibody, Aop2 antibody, phosphodiesterase 1B, Ca2+-calmodulin dependent antibody, phosphodiesterase 1B antibody, Pde1b antibody, PDE1B antibody

Background:

Description: The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE1 subfamily. Members of the PDE1 family are calmodulin-dependent PDEs that are stimulated by a calcium-calmodulin complex. This PDE has dual-specificity for the second messengers, cAMP and cGMP, with a preference for cGMP as a substrate. cAMP and cGMP function as key regulators of many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. , ,

Aliases: PDE1B1, PDES1B

Molecular Weight: 61.4 kDa

Gene ID: 5153

HGNC: 5153

Pathways: Neurotrophin Signaling Pathway, cAMP Metabolic Process, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma