PRDM1 antibody

Catalog No. ABIN1724737

Product Details anti-PRDM1 Antibody

Target: PRDM1 (PR Domain Containing 1, with ZNF Domain (PRDM1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PRDM1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purpose: PRDM1 Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human PRDM1 expressed in E. Coli.

Clone: 5E7

Isotype: IgG1

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-PRDM1 antibody (ABIN1724737)

Jiang, Gao, Sze, Xiong, Hou: "Transcription factors Xbp-1, Blimp-1, and BSAP are involved in the regulation of plasmacytic differentiation induced by 2-methoxyestradiol in myeloma cell lines." in: International journal of hematology, Vol. 86, Issue 5, pp. 429-37, (2008) (PubMed).

Barrett, Hansoul, Nicolae, Cho, Duerr, Rioux, Brant, Silverberg, Taylor, Barmada, Bitton, Dassopoulos, Datta, Green, Griffiths, Kistner, Murtha, Regueiro, Rotter, Schumm, Steinhart, Targan, Xavier et al.: "Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. ..." in: Nature genetics, Vol. 40, Issue 8, pp. 955-62, (2008) (PubMed).

Ancelin, Lange, Hajkova, Schneider, Bannister, Kouzarides, Surani: "Blimp1 associates with Prmt5 and directs histone arginine methylation in mouse germ cells." in: Nature cell biology, Vol. 8, Issue 6, pp. 623-30, (2006) (PubMed).

Target Details for PRDM1

Target: PRDM1 (PR Domain Containing 1, with ZNF Domain (PRDM1))

Alternative Name: PRDM1 (PRDM1 Products)

Background:

Description: PRDM1/Blimp1 is a repressor of beta-interferon gene expression. This action is exerted by binding to the PRDI (positive regulatory domain I element) of the beta-IFN gene promoter. The transcription of this gene is increased upon virus induction. Two alternatively spliced transcript variants that encode different isoforms have been reported.

Aliases: BLIMP1, PRDI-BF1, MGC118922, MGC118923, MGC118924, MGC118925, PRDM1

Molecular Weight: 88kDa

Gene ID: 639

HGNC: 639

UniProt: O75626

Pathways: Regulation of Muscle Cell Differentiation