TNK1 antibody (AA 451-560)
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- Target See all TNK1 Antibodies
- TNK1 (Tyrosine Kinase, Non-Receptor, 1 (TNK1))
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Binding Specificity
- AA 451-560
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This TNK1 antibody is un-conjugated
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Application
- ELISA
- Purpose
- TNK1 Antibody
- Purification
- Ascitic fluid
- Immunogen
- Purified recombinant fragment of TNK1 (aa451-560) expressed in E. Coli.
- Clone
- 1B5G3
- Isotype
- IgG1
- Top Product
- Discover our top product TNK1 Primary Antibody
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- Application Notes
- ELISA: 1/10000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Ascitic fluid containing 0.03 % sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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Thirty-eight-negative kinase 1 (TNK1) facilitates TNFalpha-induced apoptosis by blocking NF-kappaB activation." in: Oncogene, Vol. 26, Issue 45, pp. 6536-45, (2007) (PubMed).
: "Kos1, a nonreceptor tyrosine kinase that suppresses Ras signaling." in: Oncogene, Vol. 22, Issue 23, pp. 3562-77, (2003) (PubMed).
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Thirty-eight-negative kinase 1 (TNK1) facilitates TNFalpha-induced apoptosis by blocking NF-kappaB activation." in: Oncogene, Vol. 26, Issue 45, pp. 6536-45, (2007) (PubMed).
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- Target
- TNK1 (Tyrosine Kinase, Non-Receptor, 1 (TNK1))
- Alternative Name
- TNK1 (TNK1 Products)
- Synonyms
- Kos1 antibody, Tnk1a antibody, Tnk1b antibody, Ack-like antibody, tyrosine kinase non receptor 1 antibody, tyrosine kinase, non-receptor, 1 antibody, TNK1 antibody, Tnk1 antibody
- Background
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Description: TNK1: tyrosine kinase, non-receptor, 1. TNK1 is a nonreceptor tyrosine kinase(NRPTK). These kinases, like members of the SRC (MIM 190090) and JAK (see MIM 147795) families, mediate intracellular signaling downstream of receptor activation.Tnk1 is a ubiquitously expressed 47- kDa protein with autotyrosine kinase activity that is developmentally regulated during embryogenesis. Tnk1 is also upregulated following IL3 withdrawal from factor-dependent murine NSF/N1.H7 cells that undergo apoptosis, suggesting a role in growth inhibition. Data support a negative regulatory role for Tnk1 in regulating the Ras-Raf1-MAPK growth pathway by a mechanism that requires its autotyrosine kinase activity.
Aliases: MGC46193, TNK1
- Gene ID
- 8711
- HGNC
- 8711
- UniProt
- Q13470
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