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TNK1 antibody (AA 451-560)

TNK1 Reactivity: Human ELISA Host: Mouse Monoclonal 1B5G3 unconjugated
Catalog No. ABIN1724711
  • Target See all TNK1 Antibodies
    TNK1 (Tyrosine Kinase, Non-Receptor, 1 (TNK1))
    Binding Specificity
    • 15
    • 11
    • 8
    • 6
    • 6
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 451-560
    Reactivity
    • 47
    • 12
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 50
    • 7
    Mouse
    Clonality
    • 50
    • 7
    Monoclonal
    Conjugate
    • 17
    • 5
    • 5
    • 5
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This TNK1 antibody is un-conjugated
    Application
    • 36
    • 30
    • 20
    • 14
    • 14
    • 8
    • 4
    • 2
    • 1
    • 1
    ELISA
    Purpose
    TNK1 Antibody
    Purification
    Ascitic fluid
    Immunogen
    Purified recombinant fragment of TNK1 (aa451-560) expressed in E. Coli.
    Clone
    1B5G3
    Isotype
    IgG1
    Top Product
    Discover our top product TNK1 Primary Antibody
  • Application Notes
    ELISA: 1/10000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Ascitic fluid containing 0.03 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • Azoitei, Brey, Busch, Fulda, Adler, Seufferlein: "Thirty-eight-negative kinase 1 (TNK1) facilitates TNFalpha-induced apoptosis by blocking NF-kappaB activation." in: Oncogene, Vol. 26, Issue 45, pp. 6536-45, (2007) (PubMed).

    Hoare, Hoare, Smith, Kalmaz, Small, Stratford May: "Kos1, a nonreceptor tyrosine kinase that suppresses Ras signaling." in: Oncogene, Vol. 22, Issue 23, pp. 3562-77, (2003) (PubMed).

  • Target
    TNK1 (Tyrosine Kinase, Non-Receptor, 1 (TNK1))
    Alternative Name
    TNK1 (TNK1 Products)
    Synonyms
    Kos1 antibody, Tnk1a antibody, Tnk1b antibody, Ack-like antibody, tyrosine kinase non receptor 1 antibody, tyrosine kinase, non-receptor, 1 antibody, TNK1 antibody, Tnk1 antibody
    Background

    Description: TNK1: tyrosine kinase, non-receptor, 1. TNK1 is a nonreceptor tyrosine kinase(NRPTK). These kinases, like members of the SRC (MIM 190090) and JAK (see MIM 147795) families, mediate intracellular signaling downstream of receptor activation.Tnk1 is a ubiquitously expressed 47- kDa protein with autotyrosine kinase activity that is developmentally regulated during embryogenesis. Tnk1 is also upregulated following IL3 withdrawal from factor-dependent murine NSF/N1.H7 cells that undergo apoptosis, suggesting a role in growth inhibition. Data support a negative regulatory role for Tnk1 in regulating the Ras-Raf1-MAPK growth pathway by a mechanism that requires its autotyrosine kinase activity.

    Aliases: MGC46193, TNK1

    Gene ID
    8711
    HGNC
    8711
    UniProt
    Q13470
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