TYRO3 antibody (AA 138-321)

Catalog No. ABIN1724702

Product Details anti-TYRO3 Antibody

Target: TYRO3 (TYRO3 Protein Tyrosine Kinase (TYRO3))

Binding Specificity: AA 138-321

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TYRO3 antibody is un-conjugated

Application: ELISA, Immunocytochemistry (ICC)

Purpose: Tyro3 Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of Tyro3 (aa138-321) expressed in E. Coli.

Clone: 6D6F10

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-TYRO3 antibody (ABIN1724702)

Hafizi, Gustafsson, Stenhoff, Dahlbäck: "The Ran binding protein RanBPM interacts with Axl and Sky receptor tyrosine kinases." in: The international journal of biochemistry & cell biology, Vol. 37, Issue 11, pp. 2344-56, (2005) (PubMed).

Target Details for TYRO3

Target: TYRO3 (TYRO3 Protein Tyrosine Kinase (TYRO3))

Alternative Name: Tyro3 (TYRO3 Products)

Synonyms: TYRO3 antibody, brt antibody, byk antibody, dtk antibody, rse antibody, sky antibody, tif antibody, Xksy antibody, MGC145734 antibody, DKFZp469I0432 antibody, LOC100231598 antibody, BYK antibody, Dtk antibody, RSE antibody, Sky antibody, Tif antibody, Brt antibody, REK antibody, ksy antibody, xksy antibody, AI323366 antibody, Etk-2 antibody, Rse antibody, TYRO3 protein tyrosine kinase antibody, TYRO3 protein tyrosine kinase L homeolog antibody, TYRO3 protein tyrosine kinase 3 antibody, TYRO3 antibody, tyro3 antibody, Tyro3 antibody, tyro3.L antibody

Background:

Description: Tyro3 (also known as Sky and Rse), with 890-amino acid protein (about 98 kDa), belongs to the Axl/Tyro3 family of receptor tyrosine kinases, which also includes Axl and Mer.Gas6 (growth arrest-specific gene-6) is a ligand for all members of the Axl family and they play essential roles in spermatogenesis, immunoregulation, and phagocytosis.Tyro3 was expressed at high levels during postnatal development and in the adult in the cortex.Tyro3 and Gas6 have neurotrophic roles in the nervous system.In addition, the signalling interactions of Axl and Tyro3 may play roles in tumourigenesis, inflammation as well as other cell proliferative diseases.

Aliases: BYK, Brt, Dtk, RSE, Sky, Tif, FLJ16467

Gene ID: 7301

HGNC: 7301

UniProt: Q06418

Pathways: RTK Signaling