Survivin antibody

Catalog No. ABIN1724686

Product Details anti-Survivin Antibody

Target: Survivin (BIRC5) (Baculoviral IAP Repeat-Containing 5 (BIRC5))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Survivin antibody is un-conjugated

Application: ELISA

Purpose: Survivin Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of Survivin expressed in E. Coli.

Clone: 2H5H2

Isotype: IgG1

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-Survivin antibody (ABIN1724686)

Karam, Lotan, Ashfaq, Sagalowsky, Shariat: "Survivin expression in patients with non-muscle-invasive urothelial cell carcinoma of the bladder." in: Urology, Vol. 70, Issue 3, pp. 482-6, (2007) (PubMed).

Piras, Murtas, Minerba, Ugalde, Floris, Maxia, Colombari, Perra, Sirigu: "Nuclear survivin is associated with disease recurrence and poor survival in patients with cutaneous malignant melanoma." in: Histopathology, Vol. 50, Issue 7, pp. 835-42, (2007) (PubMed).

Target Details for Survivin

Target: Survivin (BIRC5) (Baculoviral IAP Repeat-Containing 5 (BIRC5))

Alternative Name: Survivin (BIRC5 Products)

Background:

Description: Baculoviral IAP repeat-containing 5 (survivin). This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors yet low in adult tissues. Antisense transcripts are involved in the regulation of this gene's expression. At least four transcript variants encoding distinct isoforms have been found for this gene, but the full-length natures of only three of them have been determined.

Aliases: API4, EPR-1, BIRC5

Gene ID: 332

HGNC: 332

UniProt: O15392

Pathways: Apoptosis, Cell Division Cycle, Nuclear Hormone Receptor Binding