SORL1 antibody

Catalog No. ABIN1724674

Product Details anti-SORL1 Antibody

Target: SORL1 (Sortilin-Related Receptor, L(DLR Class) A Repeats Containing (SORL1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This SORL1 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Purpose: SORL1 Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human SORL1 expressed in E. Coli.

Clone: 3B6B11

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-SORL1 antibody (ABIN1724674)

Shah, Yu: "sorLA: sorting out APP." in: Molecular interventions, Vol. 6, Issue 2, pp. 74-6, 58, (2006) (PubMed).

Gabrielsson, Olofsson, Sjögren, Jernås, Elander, Lönn, Rudemo, Carlsson: "Evaluation of reference genes for studies of gene expression in human adipose tissue." in: Obesity research, Vol. 13, Issue 4, pp. 649-52, (2005) (PubMed).

Scherzer, Offe, Gearing, Rees, Fang, Heilman, Schaller, Bujo, Levey, Lah: "Loss of apolipoprotein E receptor LR11 in Alzheimer disease." in: Archives of neurology, Vol. 61, Issue 8, pp. 1200-5, (2004) (PubMed).

Target Details for SORL1

Target: SORL1 (Sortilin-Related Receptor, L(DLR Class) A Repeats Containing (SORL1))

Alternative Name: SORL1 (SORL1 Products)

Background:

Description: SORL1 (sortilin-related receptor, L A repeats containing) also known as sorting protein-related receptor containing LDLR class A (SorLA), is a Type I membrane protein that may be involved in cell-cell interaction. SorLA, a single transmembrane receptor, binds LDL and transports it into cells by endocytosis. SorLA is synthesized as a proreceptor which is processed to the mature form by a furin-like propeptidase. It can also bind to RAP (receptor-associated protein). SorLA is a multifunctional endocytis receptor important in lipoprotein and protease uptake. The N-terminal propeptide, which is removed, can be cleaved by furin or homologous proteases. Endogenous SorLA binds the neuropeptide head activator (HA) and is important for HA signaling and function. The gene encoding for the protein maps to chromosome 8p23.1. SorLA is expressed mainly in brain (cerebral cortex, cerebellum and the occipital pole), but can also be found in liver, spinal cord, kidney, testis and pancreas.

Aliases: SORL1

Gene ID: 6653

HGNC: 6653

UniProt: Q92673

Pathways: Smooth Muscle Cell Migration