KAT5 antibody

Catalog No. ABIN1724672

Product Details anti-KAT5 Antibody

Target: KAT5 (K(lysine) Acetyltransferase 5 (KAT5))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This KAT5 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Purpose: TIP60 Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human TIP60 expressed in E. Coli.

Clone: 3F9

Isotype: IgG2b

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-KAT5 antibody (ABIN1724672)

Raisner, Madhani: "Patterning chromatin: form and function for H2A.Z variant nucleosomes." in: Current opinion in genetics & development, Vol. 16, Issue 2, pp. 119-24, (2006) (PubMed).

Jin, Cai, Li, Conaway, Workman, Conaway, Kusch: "In and out: histone variant exchange in chromatin." in: Trends in biochemical sciences, Vol. 30, Issue 12, pp. 680-7, (2005) (PubMed).

Target Details for KAT5

Target: KAT5 (K(lysine) Acetyltransferase 5 (KAT5))

Alternative Name: TIP60 (KAT5 Products)

Synonyms: 6121 antibody, CG6121 antibody, DmEG0007.7 antibody, Dmel/TIP60 antibody, Dmel\\CG6121 antibody, Dmel\\TIP60 antibody, EG0007.7 antibody, EG:EG0007.7 antibody, TIP60 antibody, dTIP60 antibody, dTip60 antibody, dmHAG405 antibody, im:6908768 antibody, wu:fb55b08 antibody, zgc:110752 antibody, ESA1 antibody, HTATIP antibody, HTATIP1 antibody, PLIP antibody, TIP antibody, ZC2HC5 antibody, cPLA2 antibody, AI839539 antibody, CPLA2 antibody, Htatip antibody, Htatip1 antibody, Tip55 antibody, Tip60 antibody, K(lysine) acetyltransferase 5a antibody, lysine acetyltransferase 5 antibody, Tat interactive protein 60kDa antibody, histone acetyltransferase Tip60 antibody, tip60, putative antibody, K(lysine) acetyltransferase 5b antibody, K(lysine) acetyltransferase 5 antibody, kat5a antibody, KAT5 antibody, Tip60 antibody, LOC413101 antibody, LOC5579231 antibody, Smp_053140 antibody, kat5b antibody, Kat5 antibody

Background:

Description: HTATIP (HIV-1 Tat interacting protein TIP60, about 60 kDa) belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins. The nucleosome, made up of four core histone proteins (H2A, H2B, H3 and H4), is the primary building block of chromatin. In addition to the growing number of post-translational histone modifications regulating chromatin structure, cells can also exchange canonical histones with variant histones that can directly or indirectly modulate chromatin structure. There are five major variants of histone H2A: canonical H2A (most abundant), H2A.X, MacroH2A, H2ABbd and H2A.Z. Histone H2A.Z, the most conserved variant across species, functions as both a positive and negative regulator of transcription and is important for chromosome stability. Several homologous protein complexes, such as SWR-C, TIP60 and SRCAP (mammals), have been shown to catalyze the ATP-dependent exchange of H2A.Z for H2A in the nucleosome. This protein is a histone acetylase that has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction.

Aliases: TIP60 (HTATIP)

Molecular Weight: 60kDa

Gene ID: 10524

HGNC: 10524

UniProt: Q92993

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway