MAP2K4 antibody

Catalog No. ABIN1724655

Product Details anti-MAP2K4 Antibody

Target: MAP2K4 (Mitogen-Activated Protein Kinase Kinase 4 (MAP2K4))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This MAP2K4 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA

Purpose: MAP2K4 Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of MAP2K4 expressed in E. Coli.

Clone: 2D10D8

Isotype: IgM

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-MAP2K4 antibody (ABIN1724655)

Kim, Vander Griend, Yang, Benson, Dubauskas, Yoshida, Chekmareva, Ichikawa, Sokoloff, Zhan, Karrison, Lin, Stadler, Ichikawa, Rubin, Rinker-Schaeffer: "Mitogen-activated protein kinase kinase 4 metastasis suppressor gene expression is inversely related to histological pattern in advancing human prostatic cancers." in: Cancer research, Vol. 61, Issue 7, pp. 2833-7, (2001) (PubMed).

Cuenda: "Mitogen-activated protein kinase kinase 4 (MKK4)." in: The international journal of biochemistry & cell biology, Vol. 32, Issue 6, pp. 581-7, (2000) (PubMed).

Target Details for MAP2K4

Target: MAP2K4 (Mitogen-Activated Protein Kinase Kinase 4 (MAP2K4))

Alternative Name: MAP2K4 (MAP2K4 Products)

Synonyms: JNKK antibody, JNKK1 antibody, MAPKK4 antibody, MEK4 antibody, MKK4 antibody, PRKMK4 antibody, SAPKK-1 antibody, SAPKK1 antibody, SEK1 antibody, SERK1 antibody, SKK1 antibody, Sek1 antibody, Serk1 antibody, MKK4A-l antibody, map2k4 antibody, zgc:136500 antibody, jnkk antibody, mek4 antibody, mkk4 antibody, sek1 antibody, jnkk1 antibody, serk1 antibody, xmek2 antibody, mapkk4 antibody, prkmk4 antibody, 142758_at antibody, CG9738 antibody, CT27508 antibody, D-MKK4 antibody, DMKK4 antibody, Dmel\\CG9738 antibody, JNKK2 antibody, Mpk4 antibody, SEK1/MKK4 antibody, dMKK4 antibody, dMkk4 antibody, hep antibody, ARABIDOPSIS THALIANA MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4 antibody, ATMEK4 antibody, ATMKK4 antibody, F19C24.26 antibody, F19C24_26 antibody, MAP KINASE KINASE 4 antibody, mitogen-activated protein kinase kinase 4 antibody, MKK4B antibody, zgc:194486 antibody, mitogen-activated protein kinase kinase 4 antibody, mitogen-activated protein kinase kinase 4a antibody, MAP kinase kinase 4 antibody, mitogen activated protein kinase kinase 4 antibody, mitogen-activated protein kinase kinase 4b antibody, MAP2K4 antibody, Map2k4 antibody, map2k4a antibody, map2k4 antibody, Mkk4 antibody, MKK4 antibody, map2k4b antibody

Background:

Description: MAP2K4(mitogen-activated protein kinase kinase 4), which is located on chromosome 17p11.2, with 399-amino acid protein (about 45 kDa), belongs to the family of protein kinases located upstream of the MAP kinases and responsible for their activation has been identified. MEK-4 (also called MEK4/MKK4) activates both p38 and JNK MAP kinases.
MKK4 is a central mediator in the stress activated protein kinase signaling pathway that responds to a number of cellular and environmental stressors. By phosphorylating MAP kinases such as JNK,MKK4 can ultimately transmit stress signals to nuclear transcription factors that mediate various processes including proliferation, apoptosis, and differentiation. Its distinct biological functions have been identified for MKK4 including a role in development, hepatogenesis, and metastasis suppression.

Aliases: MAP2K4

Gene ID: 6416

HGNC: 6416

UniProt: P45985

Pathways: MAPK Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades, BCR Signaling