Caspase 6 antibody (AA 181-293)

Catalog No. ABIN1714708

Product Details anti-Caspase 6 Antibody

Target: Caspase 6 (CASP6) (Caspase 6, Apoptosis-Related Cysteine Peptidase (CASP6))

Binding Specificity: AA 181-293

Reactivity: Mouse, Rat, Drosophila melanogaster

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Caspase 6 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Drosophila melanogaster, Mouse, Rat

Predicted Reactivity: Human,Dog,Cow,Pig

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Caspase-6 subunit p11

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for Caspase 6

Target: Caspase 6 (CASP6) (Caspase 6, Apoptosis-Related Cysteine Peptidase (CASP6))

Alternative Name: Caspase-6 (CASP6 Products)

Synonyms: xCaspase-6 antibody, mch2 antibody, caspase-6 antibody, zgc:112960 antibody, CASP6 antibody, casp6 antibody, Mch2 antibody, mCASP-6 antibody, MCH2 antibody, caspase 6 L homeolog antibody, caspase 6 antibody, caspase 6, apoptosis-related cysteine peptidase antibody, group XIIA secretory phospholipase A2 antibody, caspase-6 antibody, casp6.L antibody, casp6 antibody, CASP6 antibody, CpipJ_CPIJ017008 antibody, Casp6 antibody

Background:

Synonyms: Caspase-6 subunit p11, Caspase-6 p11, Apoptosis Related Cysteine Protease, Apoptotic cysteine protease MCH2, Apoptotic protease MCH 2, Apoptotic protease MCH2, Casp 6, Casp6, Caspase 6 apoptosis related cysteine protease, Caspase 6 precursor, Caspase6, Human cysteine protease Mch2 isoform alpha, Mch 2, Mch2, CASP6_HUMAN.

Background: Caspase-6 Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death. Subunit is compose of heterodimer of a18 kDa (p18) and a 11 kDa (p11) subunit. Subcellular location at cytoplasmic. Cleavages by CPP32, caspase-8 or -10 generate the two active subunits. It belongs to the peptidase C14 family.

Gene ID: 839

UniProt: P55212

Pathways: Apoptosis, Caspase Cascade in Apoptosis