CRYGS antibody (AA 101-178)

Catalog No. ABIN1714667

Product Details anti-CRYGS Antibody

Target: CRYGS (Crystallin, gamma S (CRYGS))

Binding Specificity: AA 101-178

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CRYGS antibody is un-conjugated

Application: ELISA, Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Beta crystallin S

Isotype: IgG

Application Details

Application Notes: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for CRYGS

Target: CRYGS (Crystallin, gamma S (CRYGS))

Alternative Name: Beta crystallin S (CRYGS Products)

Synonyms: AI327013 antibody, Opj antibody, rncat antibody, CRYG8 antibody, CTRCT20 antibody, crystallin, gamma S antibody, crystallin gamma S antibody, Crygs antibody, CRYGS antibody

Background:

Synonyms: AI327013, Beta-crystallin S, CRBS_HUMAN, CRYG8, crygs, Crystallin, gamma 8, Crystallin, gamma polypeptide 8, Crystallin, gamma S, Gamma crystallin S, Gamma S crystallin, Gamma-crystallin S, Gamma-S-crystallin, recessive nuclear cataract, Opj, rncat.

Background: Crystallins are separated into two classes:taxon-specific, or enzyme, and ubiquitous. The latter classconstitutes the major proteins of vertebrate eye lens and maintainsthe transparency and refractive index of the lens. Since lenscentral fiber cells lose their nuclei during development, thesecrystallins are made and then retained throughout life, making themextremely stable proteins. Mammalian lens crystallins are dividedinto alpha, beta, and gamma families, beta and gamma crystallinsare also considered as a superfamily. Alpha and beta families arefurther divided into acidic and basic groups. Seven protein regionsexist in crystallins: four homologous motifs, a connecting peptide,and N- and C-terminal extensions. Gamma-crystallins are ahomogeneous group of highly symmetrical, monomeric proteinstypically lacking connecting peptides and terminal extensions. Theyare differentially regulated after early development. This geneencodes a protein initially considered to be a beta-crystallin butthe encoded protein is monomeric and has greater sequencesimilarity to other gamma-crystallins. This gene encodes the mostsignificant gamma-crystallin in adult eye lens tissue. Whether dueto aging or mutations in specific genes, gamma-crystallins havebeen involved in cataract formation. [provided by RefSeq, Jul2008].

Gene ID: 1427