FDPS antibody (AA 201-300)

Catalog No. ABIN1714535

Product Details anti-FDPS Antibody

Target: FDPS (Farnesyl Diphosphate Synthase (FDPS))

Binding Specificity: AA 201-300

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FDPS antibody is un-conjugated

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Rat

Predicted Reactivity: Human,Mouse,Dog,Cow,Sheep,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human FDPS

Isotype: IgG

Application Details

Application Notes: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for FDPS

Target: FDPS (Farnesyl Diphosphate Synthase (FDPS))

Alternative Name: FDPS (FDPS Products)

Synonyms: CG12389 antibody, DmFPPS antibody, DmFPPSase antibody, DmFPS antibody, Dmel\\CG12389 antibody, FPS antibody, fpps antibody, fps antibody, l(2)k06103 antibody, v(2)k03514 antibody, NCU01175.1 antibody, 16.m00760 antibody, DDBDRAFT_0206220 antibody, DDBDRAFT_0215017 antibody, DDB_0206220 antibody, DDB_0215017 antibody, FPPS antibody, Ac2-125 antibody, (2E antibody, 6030492I17Rik antibody, AI256750 antibody, Fdpsl1 antibody, mKIAA1293 antibody, Farnesyl pyrophosphate synthase antibody, farnesyl diphosphate synthase antibody, farnesyl diphosphate synthase L homeolog antibody, farnesyl pyrophosphate synthase antibody, farnesyl pyrophosphate synthetase antibody, farnesyl-pyrophosphate synthetase antibody, FDP synthase antibody, Farnesyl pyrophosphate synthetase antibody, farnesyl diphosphate synthetase antibody, farnesyl pyrophosphate synthase 1 antibody, Fpps antibody, fdps antibody, fdps.L antibody, MGG_08649 antibody, TP03_0857 antibody, Tb09.160.4300 antibody, fpp antibody, BBOV_I000120 antibody, fps antibody, fpps antibody, FDPS antibody, Fdps antibody, fps1 antibody

Background:

Synonyms: 2E,6E farnesyl diphosphate synthase, 6E-farnesyl diphosphate synthase, Dimethylallyltranstransferase, Farnesyl diphosphate synthase, Farnesyl diphosphate synthetase, Farnesyl pyrophosphate synthase, Farnesyl pyrophosphate synthetase, Fdps, FPP synthase, FPP synthetase, FPPS, FPPS_HUMAN, FPS, Geranyltranstransferase.

Background: FDPS is a 419 amino acid enzyme belonging to the FPP/GGPP synthetase family. Localized to cytoplasm and peroxisome, FDPS expression is regulated by phorbol esters and polyunsaturated fatty acids. FDPS assists in cholesterol biosynthesis, post-translational protein modifications and synthesis of steroid hormones in the isoprenoid pathway.FDPS catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FDPS is inactivated by interferon-induced RSAD2, which may result in the disruption of lipid rafts at the plasma membrane. Existing as a homodimer, FDPS may have anti-viral effects when inactivated by RSAD2. Reduced activity of FDPS in liver may partly be the cause of Zellweger syndrome and neonatal adrenoleukodystrophy, both of which are known to be peroxisomal deficiency diseases.

Gene ID: 2224

Pathways: Regulation of Muscle Cell Differentiation