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MAML1 antibody (AA 401-500)

MAML1 Reactivity: Chicken ELISA, WB, IHC (p), IHC (fro), ICC, IF (cc), IF (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN1714470
  • Target See all MAML1 Antibodies
    MAML1 (Mastermind-Like 1 (MAML1))
    Binding Specificity
    • 7
    • 7
    • 6
    • 6
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 401-500
    Reactivity
    • 30
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    Chicken
    Host
    • 28
    • 1
    • 1
    Rabbit
    Clonality
    • 30
    Polyclonal
    Conjugate
    • 16
    • 4
    • 3
    • 3
    • 2
    • 2
    This MAML1 antibody is un-conjugated
    Application
    • 24
    • 20
    • 13
    • 6
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Cross-Reactivity
    Chicken
    Predicted Reactivity
    Human,Mouse,Rat,Dog,Horse
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human MAML1
    Isotype
    IgG
    Top Product
    Discover our top product MAML1 Primary Antibody
  • Application Notes
    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Expiry Date
    12 months
  • Wu, Yu, Zhang, Zhang: "Cardioprotective effect of Notch signaling on the development of myocardial infarction complicated by diabetes mellitus." in: Experimental and therapeutic medicine, Vol. 14, Issue 4, pp. 3447-3454, (2017) (PubMed).

  • Target
    MAML1 (Mastermind-Like 1 (MAML1))
    Alternative Name
    MAML1 (MAML1 Products)
    Synonyms
    mam1 antibody, mam-1 antibody, xmam1 antibody, MAML1 antibody, AI644666 antibody, AW743257 antibody, D930008C07Rik antibody, Mam-1 antibody, Mam1 antibody, mKIAA0200 antibody, mastermind like transcriptional coactivator 1 L homeolog antibody, mastermind like transcriptional coactivator 1 antibody, mastermind like 1 (Drosophila) antibody, mastermind-like transcriptional coactivator 1 antibody, maml1.L antibody, MAML1 antibody, Maml1 antibody
    Background

    Synonyms: Mam-1, Mam1, MAML 1, MAML 1, Maml1, MAML1_HUMAN, Mastermind like 1, Mastermind-like protein 1, mKIAA0200.

    Background: Notch receptors are involved in cell-fate determination in organisms as diverse as flies, frogs, and humans (1). The 'mastermind' gene has been identified in multiple genetic screens for modifiers of Notch mutations in Drosophila melanogaster (2). In Drosophila, loss-of-function mutations of Notch produce a 'neurogenic' phenotype in which cells destined to become epidermis switch fate and differentiate to neural cells (2). The human homolog, mastermind-like 1 (Mam1), localizes to nuclear bodies (2-4). Mam1 binds to the ankyrin repeat domain of all four mammalian Notch receptors, forms a DNA-binding complex with ICN and RBP-Jk, and amplifies Notch-induced transcription of Hes1 (2). Mam1 is an essential component of the transcriptional apparatus of Notch signaling (5). The gene which encodes Mam1 maps to human chromosome 5 (4).

    Gene ID
    9794
    Pathways
    Notch Signaling, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development
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