GANC antibody (AA 31-130)

Catalog No. ABIN1714452

Product Details anti-GANC Antibody

Target: GANC (Glucosidase, Alpha, Neutral C (GANC))

Binding Specificity: AA 31-130

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GANC antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (Cultured Cells) (IF (cc))

Cross-Reactivity: Human, Mouse

Predicted Reactivity: Rat,Dog,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human GANC/Neutral alphaglucosidase C

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-GANC antibody (ABIN1714452)

Wang, Liu, Wang, Yang, Li, Ding, Sun, Bai, Li: "Lycium barbarum Polysaccharide Promotes Maturation of Dendritic Cell via Notch Signaling and Strengthens Dendritic Cell Mediated T Lymphocyte Cytotoxicity on Colon Cancer Cell CT26-WT." in: Evidence-based complementary and alternative medicine : eCAM, Vol. 2018, pp. 2305683, (2018) (PubMed).

Target Details for GANC

Target: GANC (Glucosidase, Alpha, Neutral C (GANC))

Alternative Name: GANC/Neutral alphaglucosidase C (GANC Products)

Synonyms: 5830445O15Rik antibody, 9330160A12 antibody, mFLJ00088 antibody, glucosidase alpha, neutral C antibody, calpain-3 antibody, glucosidase, alpha; neutral C antibody, GANC antibody, LOC453361 antibody, ganc antibody, Ganc antibody

Background:

Synonyms: Ganc, GANC_HUMAN, Glucosidase alpha neutral C, MGC138256, Neutral alpha glucosidase C, Neutral alpha-glucosidase C, Neutral alphaglucosidase C.

Background: A key enzyme in glycogen degradation and metabolism, GANC (glucosidase, neutral C) is a 914 amino acid protein with -glucosidase activity that belongs to the glycosyl hydrolase 31 family and hydrolyzes non-reducing, terminal 1,4-linked -D-glucose residues and releases -D-glucose. The gene encoding GANC maps to human chromosome 15q15.1, a region associated with susceptibility to non-insulin-dependent (type 2) diabetes mellitus, a disease characterized by high blood glucose levels. Human chromosome 15 houses over 700 genes and comprises nearly 3 % of the human genome. Angelman syndrome, Prader-Willi syndrome, Tay-Sachs disease and Marfan syndrome are all associated with defects in chromosome 15-localized genes.

Gene ID: 2595