Thymopoietin antibody (AA 51-150)

Catalog No. ABIN1714391

Product Details anti-Thymopoietin Antibody

Target: Thymopoietin (TMPO)

Binding Specificity: AA 51-150

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Thymopoietin antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Predicted Reactivity: Human,Mouse,Rat,Cow

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human LAP2

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for Thymopoietin

Target: Thymopoietin (TMPO)

Alternative Name: LAP2 alpha (TMPO Products)

Synonyms: LAP2 antibody, CMD1T antibody, LEMD4 antibody, PRO0868 antibody, TP antibody, lap2 antibody, LAP2beta antibody, 5630400D24Rik antibody, AI195756 antibody, AI606875 antibody, AW214352 antibody, AW547477 antibody, tmpo antibody, wu:fc26f12 antibody, wu:fd21f02 antibody, wu:fi29h05 antibody, thymopoietin antibody, thymopoietin S homeolog antibody, thymopoietin a antibody, TMPO antibody, Tmpo antibody, tmpo.S antibody, tmpoa antibody

Background:

Synonyms: Isoforms beta/gamma, Lamina associated polypeptide 2 alpha, Lamina associated polypeptide 2, LAP2, Thymopoietin, Thymopoietin isoform alpha, TMPO, TP alpha, TP, LAP2 alpha, LAP2A_HUMAN.

Background: The nuclear envelope separates the nucleoplasm from the cytoplasm in eukaryotic cells and includes the outer and inner nuclear membrane, nuclear pore complexes and the nuclear lamina. The nuclear lamina contains intermediate filament-type proteins called lamins that form a dense network to strengthen and stabilize the nuclear envelope. Lamina-associated polypeptide 2 (LAP2) is also known as thymopoietin. LAP2 is a nuclear envelope protein and contains an amino-terminal region called the LAP2-emerin-MAN1 or LEM motif. LAP2 also contains a unique DNA-binding amino-terminal domain. Alternative splicing produces six isoforms (, _,_, and ) of mammalian LAP2 and three isoforms in Xenopus LAP2. LAP2 and LAP2_ associate with chromosomal barrier-to-autointegration factor (BAF) and may play a role in stabilizing chromatin structure. LAP2_ also binds to lamin B. LAP2 is a non-membrane isoform of LAP2 that associates with the internal nucleoskeleton and binds lamin A. The gene encoding human LAP2 maps to chromosome 12q23.1.