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GUCA1B antibody (AA 21-120)

GUCA1B Reactivity: Human WB, ELISA, IF (p), IHC (fro), IHC (p), ICC, IF (cc) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN1714375
  • Target See all GUCA1B Antibodies
    GUCA1B (Guanylate Cyclase Activator 1B (Retina) (GUCA1B))
    Binding Specificity
    • 14
    • 8
    • 1
    • 1
    • 1
    AA 21-120
    Reactivity
    • 26
    • 11
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Human
    Host
    • 26
    • 1
    Rabbit
    Clonality
    • 26
    • 1
    Polyclonal
    Conjugate
    • 10
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This GUCA1B antibody is un-conjugated
    Application
    Western Blotting (WB), ELISA, Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunofluorescence (Cultured Cells) (IF (cc))
    Predicted Reactivity
    Human,Mouse,Rat,Cow,Sheep,Horse,Rabbit
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human GCAP2
    Isotype
    IgG
    Top Product
    Discover our top product GUCA1B Primary Antibody
  • Application Notes
    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Expiry Date
    12 months
  • Target
    GUCA1B (Guanylate Cyclase Activator 1B (Retina) (GUCA1B))
    Alternative Name
    GCAP2 (GUCA1B Products)
    Synonyms
    GUCA1B antibody, BC018258 antibody, GCAP2 antibody, GUCA2 antibody, RP48 antibody, guanylate cyclase activator 1B antibody, guanylate cyclase activator 1B (retina) antibody, GUCA1B antibody, guca1b antibody, Guca1b antibody
    Background

    Synonyms: GCAP 2, Guanylate Cyclase Activating Protein Photoreceptor 2, Guanylate Cyclase Activator 1B, Guanylin 2, Guanylyl cyclase-activating protein 2, GUC1B_HUMAN, GUCA 2, GUCA1B.

    Background: The intracellular stimulation of guanylate cyclase (GC) by calcium, a key event in the recovery of the dark state of rod photoreceptors after exposure to light, is mediated by guanylate cyclase-activating protein (GCAP1). GCAPs are calcium-binding proteins belonging to the calmodulin superfamily. GCAP1 is a calcium-binding protein that stimulates synthesis of cGMP in photoreceptors. GCAP1 is present in rod and cone photoreceptor outer segments where phototransduction occurs. In contrast to other calcium-binding proteins from the calmodulin superfamily, the calcium-free form of GCAP1 stimulates the effector enzyme. By molecular cloning of human and mouse GCAP cDNA, the known mammalian GCAPs are found to be more than 90 % similar, consisting of 201 to 205 amino acids and containing three identically conserved calcium-binding sites. A related protein, GCAP2, is detectable only in the retina and results from a gene duplication event. The genes which encode GCAP1 and GCAP2 map to human chromosome 6p21.1.

    Gene ID
    2979
    Pathways
    Regulation of G-Protein Coupled Receptor Protein Signaling, Phototransduction
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