MEGF10 antibody (AA 55-150)

Catalog No. ABIN1714211

Product Details anti-MEGF10 Antibody

Target: MEGF10 (Multiple EGF-Like-Domains 10 (MEGF10))

Binding Specificity: AA 55-150

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MEGF10 antibody is un-conjugated

Application: ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)

Cross-Reactivity: Mouse

Predicted Reactivity: Human,Rat,Dog,Cow,Sheep,Pig,Horse,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human MEGF10

Isotype: IgG

Application Details

Application Notes: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for MEGF10

Target: MEGF10 (Multiple EGF-Like-Domains 10 (MEGF10))

Alternative Name: MEGF10 (MEGF10 Products)

Synonyms: EMARDD antibody, 3000002B06Rik antibody, Gm331 antibody, multiple EGF-like domains 10 antibody, multiple EGF like domains 10 antibody, multiple EGF-like-domains 10 antibody, Megf10 antibody, MEGF10 antibody

Background:

Synonyms: MEG10_HUMAN, MEGF protein, megf10, Multiple EGF-like domains protein 10, multiple EGF-like-domains 10, Multiple epidermal growth factor-like domains 10, Multiple epidermal growth factor-like domains protein 10.

Background: MEGF10 is a 1,140 amino acid protein encoded by the human gene MEGF10. MEGF10 belongs to the MEGF family and contains fifteen EGF-like domains and one EMI domain. The engulfment of dying cells is a specialized form of phagocytosis that is highly conserved across evolution and is mediated by the concerted action of several molecules. MEGF10 is an engulfment receptor protein that localizes to the plasma membrane in a punctuated pattern. The MEGF10 protein shares structural similarities with nematode engulfment receptor cell death abnormal-1 (CED-1). MEGF10 function is modulated by the ATP binding cassette transporter ABCA1, which is an ortholog to CED-7. It is expressed at the cell surface in clusters around cell corpses during engulfment, and during the engulfment of apoptotic thymocytes is recruited to the bottom of the forming phagocytic cup.

Gene ID: 84466

Pathways: Regulation of Muscle Cell Differentiation