GSK3 alpha/beta antibody (AA 151-250)

Catalog No. ABIN1714094

Product Details anti-GSK3 alpha/beta Antibody

Target: GSK3 alpha/beta (GSK3a/b) (Glycogen Synthase Kinase 3 alpha/beta (GSK3a/b))

Binding Specificity: AA 151-250

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GSK3 alpha/beta antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)

Cross-Reactivity: Rat

Predicted Reactivity: Human,Mouse,Dog,Pig,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human GSK3 Alpha + Beta

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-GSK3 alpha/beta antibody (ABIN1714094)

Freese, Reinhardt, Hefner, Unger, Kirkpatrick, Endres: "A novel blood-brain barrier co-culture system for drug targeting of Alzheimer's disease: establishment by using acitretin as a model drug." in: PLoS ONE, Vol. 9, Issue 3, pp. e91003, (2014) (PubMed).

Target Details for GSK3 alpha/beta

Target: GSK3 alpha/beta (GSK3a/b) (Glycogen Synthase Kinase 3 alpha/beta (GSK3a/b))

Alternative Name: GSK3 Alpha + Beta (GSK3a/b Products)

Background:

Synonyms: Gsk3a, GSK 3 alpha, GSK-3 alpha, GSK3 alpha, Glycogen synthase kinase-3 alpha, GSK 3 alpha, DKFZp686D0638, GSK 3A, GSK3A, GSK3alpha, GSK3A_HUMAN, Glycogen synthase kinase 3 alpha, Serine/threonine-protein kinase GSK3A, Glycogen synthase kinase 3 beta, GSK 3 beta, GSK 3B, GSK3B, GSK3B protein, GSK3beta isoform, GSK3 beta, Glycogen synthase kinase-3 beta, GSK-3 beta, GSK3B_HUMAN, Serine/threonine-protein kinase GSK3B.

Background: The protein encoded by this gene is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It is involved in energy metabolism, neuronal cell development, and body pattern formation. Polymorphisms in this gene have been implicated in modifying risk of Parkinson disease, and studies in mice show that overexpression of this gene may be relevant to the pathogenesis of Alzheimer disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009].