UBR5 antibody (AA 11-120)

Catalog No. ABIN1714090

Product Details anti-UBR5 Antibody

Target: UBR5 (Ubiquitin Protein Ligase E3 Component N-Recognin 5 (UBR5))

Binding Specificity: AA 11-120

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UBR5 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Mouse

Predicted Reactivity: Human,Rat,Dog,Sheep,Pig,Horse,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human EDD

Isotype: IgG

Application Details

Application Notes: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for UBR5

Target: UBR5 (Ubiquitin Protein Ligase E3 Component N-Recognin 5 (UBR5))

Alternative Name: UBR5 (UBR5 Products)

Synonyms: DD5 antibody, EDD antibody, EDD1 antibody, HYD antibody, 4432411E13Rik antibody, AW549941 antibody, C77315 antibody, D030042K14 antibody, Edd antibody, Edd1 antibody, mKIAA0896 antibody, Dd5 antibody, Rat100 antibody, ubiquitin protein ligase E3 component n-recognin 5 antibody, UBR5 antibody, Ubr5 antibody

Background:

Synonyms: 4432411E13Rik, AW549941, C77315, D030042K14, DD5, E3 identied by dferential display, E3 ubiquitin protein ligase, HECT domain containing, 1, E3 ubiquitin-protein ligase, E3 ubiquitin-protein ligase UBR5, EDD 1, EDD, EDD, EDD1, FLJ11310, HECT domain-containing 1, hHYD, HYD, Hyperplastic discs protein homolog, KIAA0896, MGC57263, mKIAA0896, Progestin induced protein, Progestin-induced protein, Rat100, Ubiquitin protein ligase, Ubiquitin protein ligase E3 component n recognin 5, UBR5, UBR5_HUMAN.

Background: EDD is a progestin-regulated gene that was isolated from T-47D human breast cancer cells. Based on sequence homology, EDD appears to be a human homolog of the Drosophila hyperplastic discs (hyd) gene, a tumor suppressor gene that is required for control of imaginal disc growth. EDD contains a HECT domain in the carboxy terminus. HECT domain-containing proteins function as ubiquitin-protein ligases, or E3 enzymes. EDD has been shown to bind to ubiquitin, and like other HECT family proteins, may function as an E3 ubiquitin-protein ligase.

Gene ID: 51366

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway