MAPKSP1 antibody (AA 5-100)

Catalog No. ABIN1714007

Product Details anti-MAPKSP1 Antibody

Target: MAPKSP1 (Mitogen-Activated Protein Kinase Kinase 1 Interacting Protein 1 (MAPKSP1))

Binding Specificity: AA 5-100

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAPKSP1 antibody is un-conjugated

Application: ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)

Cross-Reactivity: Mouse

Predicted Reactivity: Human,Rat,Cow,Chicken,Zebrafish

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human MAP2K1IP1

Isotype: IgG

Application Details

Application Notes: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for MAPKSP1

Target: MAPKSP1 (Mitogen-Activated Protein Kinase Kinase 1 Interacting Protein 1 (MAPKSP1))

Alternative Name: MAP2K1IP1 (MAPKSP1 Products)

Background:

Synonyms: LAMTOR3, Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3, LTOR3_HUMAN, MAP2K1IP1, MEK binding partner 1, MEK partner 1, MEK-binding partner 1, Mitogen activated protein kinase kinase 1 interacting protein 1, Mitogen-activated protein kinase kinase 1-interacting protein 1, Mitogen-activated protein kinase scaffold protein 1, MP1, Ragulator complex protein LAMTOR3.

Background: This gene encodes a scaffold protein that functions in the extracellular signal-regulated kinase (ERK) cascade. The protein is localized to late endosomes by the mitogen-activated protein-binding protein-interacting protein, and binds specifically to MAP kinase kinase MAP2K1/MEK1, MAP kinase MAPK3/ERK1, and MAP kinase MAPK1/ERK2. Studies of the orthologous gene in mouse indicate that it regulates late endosomal traffic and cell proliferation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 13. [provided by RefSeq, Aug 2011]

Pathways: PI3K-Akt Signaling