NOB1 antibody

Catalog No. ABIN1713871

Product Details anti-NOB1 Antibody

Target: NOB1 (RNA-Binding Protein NOB1 (NOB1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NOB1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human NOB1

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for NOB1

Target: NOB1 (RNA-Binding Protein NOB1 (NOB1))

Alternative Name: NOB1 (NOB1 Products)

Synonyms: MEE6.26 antibody, MEE6_26 antibody, Nob1p antibody, fc27e05 antibody, si:ch73-167i17.3 antibody, wu:fc27e05 antibody, ART-4 antibody, MST158 antibody, NOB1P antibody, PSMD8BP1 antibody, 1700021I09Rik antibody, Psmd8bp1 antibody, NIN1/PSMD8 binding protein 1 homolog antibody, RNA-binding NOB1-like protein antibody, RNA-binding protein nob1 antibody, RNA-binding protein NOB1 antibody, NIN1/RPN12 binding protein 1 homolog S homeolog antibody, NIN1/RPN12 binding protein 1 homolog (S. cerevisiae) antibody, NIN1/RPN12 binding protein 1 homolog antibody, NOB1 antibody, AT5G41190 antibody, EDI_130960 antibody, CpipJ_CPIJ012739 antibody, BDBG_01281 antibody, PAAG_04204 antibody, PITG_13300 antibody, nob1.S antibody, nob1 antibody, Nob1 antibody

Background:

Synonyms: Adenocarcinoma antigen recognized by T lymphocytes 4, ART4, MST158, MSTP158, Nin one binding protein, NIN1/RPN12 binding protein 1 homolog S. cerevisiae, nob1, NOB1_HUMAN, NOB1P, Phosphorylation regulatory protein HP-10, Protein ART-4, Protein ART4, PSMD8 binding protein 1, PSMD8BP1, RNA binding protein NOB1, RNA-binding protein NOB1.

Background: NOB1P is a 412 amino acid nuclear protein that is involved in proteosome biogenesis and is required for the final step in 18S rRNA maturation. NOB1P contains a PIN domain, which functions as a nuclease in nonsense-mediated mRNA decay and is required for pre-rRNA cleavage. NOB1P interacts with Rent2, which is involved in nonsense-mediated decay of mRNAs containing premature stop codons. Expressed in placenta, spleen, endothelial cells, liver and lung, NOB1P is essential for the synthesis of 40S ribosome subunits. Supression of the gene encoding NOB1P inhibits the processing of the 20S pre-rRNA to the mature 18S rRNA, therefore leading to accumulation of high levels of 20S pre-rRNA with degradation intermediates.

Gene ID: 28987

Pathways: Protein targeting to Nucleus