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NOB1 antibody

NOB1 Reactivity: Human, Mouse, Rat WB, IF (p), IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN1713871
  • Target See all NOB1 Antibodies
    NOB1 (RNA-Binding Protein NOB1 (NOB1))
    Reactivity
    • 52
    • 23
    • 20
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 51
    • 2
    Rabbit
    Clonality
    • 51
    • 2
    Polyclonal
    Conjugate
    • 20
    • 6
    • 5
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This NOB1 antibody is un-conjugated
    Application
    • 43
    • 20
    • 12
    • 8
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Cross-Reactivity
    Human, Mouse, Rat
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human NOB1
    Isotype
    IgG
    Top Product
    Discover our top product NOB1 Primary Antibody
  • Application Notes
    WB 1:300-5000
    IHC-P 1:200-400
    IF(IHC-P) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Expiry Date
    12 months
  • Target
    NOB1 (RNA-Binding Protein NOB1 (NOB1))
    Alternative Name
    NOB1 (NOB1 Products)
    Synonyms
    MEE6.26 antibody, MEE6_26 antibody, Nob1p antibody, fc27e05 antibody, si:ch73-167i17.3 antibody, wu:fc27e05 antibody, ART-4 antibody, MST158 antibody, NOB1P antibody, PSMD8BP1 antibody, 1700021I09Rik antibody, Psmd8bp1 antibody, NIN1/PSMD8 binding protein 1 homolog antibody, RNA-binding NOB1-like protein antibody, RNA-binding protein nob1 antibody, RNA-binding protein NOB1 antibody, NIN1/RPN12 binding protein 1 homolog S homeolog antibody, NIN1/RPN12 binding protein 1 homolog (S. cerevisiae) antibody, NIN1/RPN12 binding protein 1 homolog antibody, NOB1 antibody, AT5G41190 antibody, EDI_130960 antibody, CpipJ_CPIJ012739 antibody, BDBG_01281 antibody, PAAG_04204 antibody, PITG_13300 antibody, nob1.S antibody, nob1 antibody, Nob1 antibody
    Background

    Synonyms: Adenocarcinoma antigen recognized by T lymphocytes 4, ART4, MST158, MSTP158, Nin one binding protein, NIN1/RPN12 binding protein 1 homolog S. cerevisiae, nob1, NOB1_HUMAN, NOB1P, Phosphorylation regulatory protein HP-10, Protein ART-4, Protein ART4, PSMD8 binding protein 1, PSMD8BP1, RNA binding protein NOB1, RNA-binding protein NOB1.

    Background: NOB1P is a 412 amino acid nuclear protein that is involved in proteosome biogenesis and is required for the final step in 18S rRNA maturation. NOB1P contains a PIN domain, which functions as a nuclease in nonsense-mediated mRNA decay and is required for pre-rRNA cleavage. NOB1P interacts with Rent2, which is involved in nonsense-mediated decay of mRNAs containing premature stop codons. Expressed in placenta, spleen, endothelial cells, liver and lung, NOB1P is essential for the synthesis of 40S ribosome subunits. Supression of the gene encoding NOB1P inhibits the processing of the 20S pre-rRNA to the mature 18S rRNA, therefore leading to accumulation of high levels of 20S pre-rRNA with degradation intermediates.

    Gene ID
    28987
    Pathways
    Protein targeting to Nucleus
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