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GRB7 antibody (AA 231-330)

GRB7 Reactivity: Human ELISA, IF (cc), IF (p), IHC (p), ICC, IHC (fro) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN1713833
  • Target See all GRB7 Antibodies
    GRB7 (Growth Factor Receptor-Bound Protein 7 (GRB7))
    Binding Specificity
    • 14
    • 7
    • 7
    • 6
    • 6
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 231-330
    Reactivity
    • 58
    • 15
    • 13
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 55
    • 3
    • 1
    • 1
    Rabbit
    Clonality
    • 59
    • 1
    Polyclonal
    Conjugate
    • 29
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This GRB7 antibody is un-conjugated
    Application
    • 36
    • 26
    • 12
    • 12
    • 10
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Predicted Reactivity
    Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Chicken,Rabbit
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human GRB7
    Isotype
    IgG
    Top Product
    Discover our top product GRB7 Primary Antibody
  • Application Notes
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Expiry Date
    12 months
  • Target
    GRB7 (Growth Factor Receptor-Bound Protein 7 (GRB7))
    Alternative Name
    GRB7 (GRB7 Products)
    Synonyms
    GRB7 antibody, mKIAA4028 antibody, growth factor receptor bound protein 7 antibody, GRB7 antibody, Grb7 antibody
    Background

    Synonyms: B47, Epidermal growth factor receptor GRB 7, Epidermal growth factor receptor GRB-7, GRB7 adapter protein, GRB7, GRB7_HUMAN, Growth factor receptor bound protein 7, Growth factor receptor-bound protein 7, OTTHUMP00000164349, OTTHUMP00000164350, OTTHUMP00000164351, OTTHUMP00000164352.

    Background: Many growth factors function by binding receptors with intrinsic tyrosine kinase activity (1,2). Signaling by such receptors involves a series of intermediates characterized by SH2 domains that bind tyrosine phosphorylated receptors by a direct interaction between the SH2 domain and the phosphotyrosine-containing receptor sequences (3,4). GRB7, a SH2 domain protein, has a single SH2 domain at its C-terminal, a central region with similarity to Ras GAP and a proline-rich N-terminus (5,6). GRB7 maps to the region on mouse chromosome 11 containing the Neu gene (6). This region of mouse chromosome 11 is syntenic to an area of human chromosome 17q that is frequently amplified in breast cancer (6,7). Moreover, GRB7 is amplified and over-expressed in breast cancer and is found in a complex with Neu gp185 (6).

    Pathways
    EGFR Signaling Pathway, Ribonucleoprotein Complex Subunit Organization
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