Chloride Channel 5 antibody (AA 1-100)

Catalog No. ABIN1713746

Product Details anti-Chloride Channel 5 Antibody

Target: Chloride Channel 5 (CLCN5)

Binding Specificity: AA 1-100

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Chloride Channel 5 antibody is un-conjugated

Application: ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Chloride Channel 5/CLC5

Isotype: IgG

Application Details

Application Notes: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for Chloride Channel 5

Target: Chloride Channel 5 (CLCN5)

Alternative Name: Chloride Channel 5 (CLCN5 Products)

Synonyms: CLCN3 antibody, CLCN5 antibody, clcn5-A antibody, DKFZp469O2315 antibody, 5430408K11Rik antibody, ClC-5 antibody, Clc5 antibody, D930009B12Rik antibody, DXImx42e antibody, Sfc13 antibody, T25545 antibody, CLC5 antibody, CLCK2 antibody, DENTS antibody, NPHL1 antibody, NPHL2 antibody, XLRH antibody, XRN antibody, hCIC-K2 antibody, CLCN4 antibody, Clcn5 antibody, chloride voltage-gated channel 5 antibody, chloride channel, voltage-sensitive 5 L homeolog antibody, chloride channel, voltage-sensitive 5 antibody, CLCN5 antibody, clcn5.L antibody, clcn5 antibody, Clcn5 antibody

Background:

Synonyms: Chloride channel protein 5, Chloride transporter ClC-5, ClC-5, CLC5, CLCK2, CLCN5, CLCN5_HUMAN, DENTS, H+/Cl- exchange transporter 5, hCIC-K2, NPHL1, NPHL2, XLRH, XRN.

Background: The family of voltage-dependent chloride channels (CLCs) regulate cellular trafficking of chloride ions, a critical component of all living cells. CLCs regulate excitability in muscle and nerve cells, aid in organic solute transport and maintain cellular volume. The genes encoding human CLC-1 through CLC-7 map to chromosomes 7q32, 3q28, 4q32, Xp22.3, Xp11.23-p11.22, 1p36 and 16p13, respectively. CLC1 is highly expressed in skeletal muscle. Mutations in the gene encoding CLC1 lead to myotonia, an inheritable disorder characterized by muscle stiffness and renal salt wasting. CLC2 is highly expressed in the epithelia of several organs including lung, which suggests CLC2 may be a possible therapeutic target for cystic fibrosis. CLC3 expression is particularly abundant in neuronal tissue, while CLC4 expression is evident in skeletal and cardiac muscle as well as brain. Mutations in the gene encoding CLC5 lead to Dent?s disease, a renal disorder characterized by proteinuria and hypercalciuria. CLC6 and CLC7 are broadly expressed in several tissues including testis, kidney, brain and muscle.