MS4A15 antibody (AA 31-130)

Catalog No. ABIN1713561

Product Details anti-MS4A15 Antibody

Target: MS4A15 (Membrane-Spanning 4-Domains, Subfamily A, Member 15 (MS4A15))

Binding Specificity: AA 31-130

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MS4A15 antibody is un-conjugated

Application: ELISA, Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunofluorescence (Cultured Cells) (IF (cc))

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human MS4A15

Isotype: IgG

Application Details

Application Notes: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for MS4A15

Target: MS4A15 (Membrane-Spanning 4-Domains, Subfamily A, Member 15 (MS4A15))

Alternative Name: MS4A15 (MS4A15 Products)

Synonyms: E530011F12Rik antibody, Gm1286 antibody, membrane spanning 4-domains A15 antibody, membrane-spanning 4-domains, subfamily A, member 15 antibody, MS4A15 antibody, Ms4a15 antibody

Background:

Synonyms: FLJ34527, Hypothetical protein MGC35295, M4A15_HUMAN, Membrane spanning 4 domains subfamily A member 15, Membrane-spanning 4-domains subfamily A member 15, MGC35295, MS4A15.

Background: MS4A (membrane-spanning 4-domain family, subfamily A) is a large family of proteins that includes at least 26 members in mouse and humans. Flanked by amino- and carboxyl- cytoplasmic regions, MS4A family members contain four highly conserved transmembrane domains. CD20, the most well-known MS4A family member, is a B-cell-specific molecule that functions as a calcium-permeable cation channel and is known to accelerate the G0 to G1 progression induced by IGF-1. MS4A15 (membrane-spanning 4-domains, subfamily A, member 15) is a 240 amino acid multi-pass membrane protein that exists as two alternatively spliced isoforms. The gene encoding MS4A15 maps to human chromosome 11, which houses over 1,400 genes and comprises nearly 4 % of the human genome. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are associated with defects in genes that maps to chromosome 11.