FNBP1 antibody (AA 331-430) (HRP)

Catalog No. ABIN1712049

Product Details anti-FNBP1 Antibody (HRP)

Target: FNBP1 (Formin Binding Protein 1 (FNBP1))

Binding Specificity: AA 331-430

Reactivity: Pufferfish, Xenopus laevis

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FNBP1 antibody is conjugated to HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Pufferfish, Xenopus laevis

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Sheep,Horse,Zebrafish

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human FBP17

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for FNBP1

Target: FNBP1 (Formin Binding Protein 1 (FNBP1))

Alternative Name: FBP17 (FNBP1 Products)

Synonyms: MGC122623 antibody, MGC146466 antibody, FBP17 antibody, 1110057E06Rik antibody, 2210010H06Rik antibody, FBP1 antibody, Fbp17 antibody, formin binding protein 1 antibody, formin binding protein 1 L homeolog antibody, FNBP1 antibody, fnbp1 antibody, Fnbp1 antibody, fnbp1.L antibody

Background:

Synonyms: FBP1, FBP17, FNBP1, FNBP1_HUMAN, Formin binding protein 1, Formin binding protein 17, Formin-binding protein 1, Formin-binding protein 17, hFBP17, KIAA0554, MGC126804.

Background: FNBP1 is a 617 amino acid protein that localizes to a variety of locations within the cell, including the cytoplasm, cytoskeleton, lysosome and the cell cortex, and contains one FCH domain, one REM repeat and one SH3 domain. Expressed at high levels in respiratory, reproductive and urinary systems, as well as in brown adipose tissue and epithelial cells of the gastrointestinal tract, FNBP1 interacts with Rho 7 and links the Actin cytoskeleton with Rho 7 signaling, playing a crucial role in membrane tubulation and cytoskeletal reorganization during endocytosis. Additionally, FNBP1, which exists as four alternatively spliced isoforms, enhances Actin polymerization and promotes membrane invagination and the formation of tubules. Chromosomal aberrations in the FNBP1 gene are associated with acute leukemias, suggesting a role for defective FNBP1 in carcinogenesis.

Gene ID: 23048