METTL18 antibody (AA 121-220) (HRP)

Catalog No. ABIN1711636

Product Details anti-METTL18 Antibody (HRP)

Target: METTL18 (Methyltransferase Like 18 (METTL18))

Binding Specificity: AA 121-220

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This METTL18 antibody is conjugated to HRP

Application: ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Cross-Reactivity: Human

Predicted Reactivity: Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human C1orf156

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for METTL18

Target: METTL18 (Methyltransferase Like 18 (METTL18))

Alternative Name: C1orf156 (METTL18 Products)

Synonyms: ASTP2 antibody, C16H1orf156 antibody, C1orf156 antibody, AsTP2 antibody, HPM1 antibody, 2810422O20Rik antibody, C78571 antibody, RGD1306783 antibody, methyltransferase like 18 antibody, METTL18 antibody, Mettl18 antibody

Background:

Synonyms: Arsenic-transactivated protein 2, AsTP2, Histidine protein methyltransferase 1 homolog, HPM1, MET18_HUMAN, Methyltransferase like 18, Methyltransferase-like protein 18, Mettl18, MGC9084, RP1-117P20.4.

Background: Chromosome 1 is the largest human chromosome spanning about 260 million base pairs and making up 8 % of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1. A breakpoint has been identified in 1q which disrupts the DISC1 gene and is linked to schizophrenia. Aberrations in chromosome 1 are found in a variety of cancers including head and neck cancer, malignant melanoma and multiple myeloma. The C1orf156 gene product has been provisionally designated C1orf156 pending further characterization.

Gene ID: 92342