DOCK4 antibody (AA 1001-1100) (FITC)

Catalog No. ABIN1709848

Product Details anti-DOCK4 Antibody (FITC)

Target: DOCK4 (Dedicator of Cytokinesis 4 (DOCK4))

Binding Specificity: AA 1001-1100

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DOCK4 antibody is conjugated to FITC

Application: Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human DOCK4

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for DOCK4

Target: DOCK4 (Dedicator of Cytokinesis 4 (DOCK4))

Alternative Name: DOCK4 (DOCK4 Products)

Synonyms: DOCK4 antibody, 5330406C03 antibody, 6330411N01Rik antibody, AF263288 antibody, C030023J22 antibody, mKIAA0716 antibody, dedicator of cytokinesis 4 antibody, DOCK4 antibody, NAEGRDRAFT_81257 antibody, Dock4 antibody

Background:

Synonyms: Dedicator of cytokinesis protein 4, Dock4, DOCK4_HUMAN, KIAA0716.

Background: DOCK 4 is a cytoplasmic peripheral membrane protein that belongs to the DOCK family of cytokinesis-regulating proteins. Expressed ubiquitously with highest expression in prostate, ovary and skeletal muscle, DOCK 4 functions as a guanine nucleotide exchange factor (GEF) that activates the small GTPase Rap 1 and, via this activation, plays a role in the regulation of adherens junctions between cells. Similar to other DOCK family members, DOCK 4 contains an N-terminal SH3 domain, a C-terminal proline-rich region and two internal DOCK homology regions designated DHR1 and DHR2. Defects in the gene encoding DOCK 4 result in the inactivation of Rap 1 and are, thus, implicated in the pathogenesis of various cancers such as ovarian, prostate, glioma and colorectal carcinomas. Four isoforms of DOCK 4 are expressed due to alternative splicing events.

Gene ID: 9732