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BORA antibody (AA 31-130) (Cy7)

BORA Reactivity: Human WB, IF (cc), IF (p) Host: Rabbit Polyclonal Cy7
Catalog No. ABIN1708559
  • Target See all BORA Antibodies
    BORA (Protein Aurora Borealis (BORA))
    Binding Specificity
    • 14
    • 7
    • 6
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 31-130
    Reactivity
    • 44
    • 13
    • 13
    Human
    Host
    • 41
    • 2
    • 1
    Rabbit
    Clonality
    • 44
    Polyclonal
    Conjugate
    • 13
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This BORA antibody is conjugated to Cy7
    Application
    • 23
    • 12
    • 12
    • 12
    • 7
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Predicted Reactivity
    Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Rabbit
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human BORA
    Isotype
    IgG
    Top Product
    Discover our top product BORA Primary Antibody
  • Application Notes
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Expiry Date
    12 months
  • Target
    BORA (Protein Aurora Borealis (BORA))
    Alternative Name
    BORA (BORA Products)
    Synonyms
    CG6897 antibody, Dmel\\CG6897 antibody, zgc:101616 antibody, C13orf34 antibody, 6720463M24Rik antibody, AI317232 antibody, RGD1309522 antibody, c13orf34 antibody, C12H13orf34 antibody, aurora borealis antibody, bora, aurora kinase A activator antibody, protein aurora borealis antibody, bora, aurora kinase A activator S homeolog antibody, bora antibody, Tsp_06066 antibody, Bora antibody, BORA antibody, bora.S antibody
    Background

    Synonyms: Aurora borealis, bora, BORA_HUMAN, C13orf34, Chromosome 13 open reading frame 34, FLJ22624, HsBora, Protein aurora borealis, RP11-342J4.2.

    Background: Aurora related kinase-1 (ARK-1) is a centrosome-associated serine/threonine kinase that regulates centrosome separation, bipolar spindle assembly and chromosome segregation during mitosis. Bora (protein aurora borealis) is a 559 amino acid protein that activates ARK-1. Bora is localized to the nucleus until mitosis is initiated, when it then translocates to the cytoplasm. This translocation is dependent on activated Cdc2, which releases Bora to bind and activate ARK-1 in the cytoplasm. Plk (polo-like kinase) interacts with Bora to control the accessibility of its activation loop for phosphorylation and activation on its N-terminus by ARK-1. It is through this mechanism that Bora and ARK-1 control cellular mitotic entry. Downregulation of the gene encoding Bora results in multipolar spindles in mitosis, a phenomenon that is also observed when ARK-1 function is blocked.

    Gene ID
    79866
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