SP6 antibody (AA 201-300) (Biotin)

Catalog No. ABIN1701375

Product Details anti-SP6 Antibody (Biotin)

Target: SP6 (Sp6 Transcription Factor (SP6))

Binding Specificity: AA 201-300

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SP6 antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Pig,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human SP6

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for SP6

Target: SP6 (Sp6 Transcription Factor (SP6))

Alternative Name: SP6 (SP6 Products)

Synonyms: xsp6 antibody, MGC131081 antibody, EPFN antibody, EPIPROFIN antibody, KLF14 antibody, 1110025J03Rik antibody, AA591031 antibody, AI592962 antibody, Epfn antibody, Klf14 antibody, Sp6 transcription factor antibody, Sp5 transcription factor L homeolog antibody, trans-acting transcription factor 6 antibody, SP6 antibody, sp5.L antibody, Sp6 antibody

Background:

Synonyms: MGC119665, Epfn, EPIPROFIN, KLF14, Krueppel-like factor 14, MGC119662, MGC119663, MGC119664, Sp6, Sp6 transcription factor, SP6_HUMAN, Transcription factor Sp6.

Background: Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. Sp6, also known as EPFN, EPIPROFIN or KLF14, is a 376 amino acid protein that localizes to the nucleus and contains three C2H2-type zinc fingers. Expressed ubiquitously with higher expression in developing teeth, hair follicles and limb buds, Sp6 functions to bind GC-rich sequences and related GT and CACCC boxes, thereby promoting cellular proliferation. Human Sp6 shares 96 % sequence homology with its mouse counterpart, suggesting a conserved role between species. The gene encoding Sp6 maps to human chromosome 17, which comprises over 2.5 % of the human genome and encodes over 1,200 genes.