AIPL1 antibody (AA 165-260) (Biotin)

Catalog No. ABIN1701149

Product Details anti-AIPL1 Antibody (Biotin)

Target: AIPL1 (Aryl Hydrocarbon Receptor Interacting Protein-Like 1 (AIPL1))

Binding Specificity: AA 165-260

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AIPL1 antibody is conjugated to Biotin

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human AIPL1

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for AIPL1

Target: AIPL1 (Aryl Hydrocarbon Receptor Interacting Protein-Like 1 (AIPL1))

Alternative Name: AIPL1 (AIPL1 Products)

Synonyms: AIPL1 antibody, lca4 antibody, aipl2 antibody, AIPL2 antibody, LCA4 antibody, A930007I01Rik antibody, aryl hydrocarbon receptor interacting protein like 1 antibody, aryl hydrocarbon receptor-interacting protein-like 1 antibody, AIPL1 antibody, aipl1 antibody, Aipl1 antibody

Background:

Synonyms: A930007I01Rik, Aipl1, AIPL1_HUMAN, AIPL2, Aryl hydrocarbon interacting protein like 1, Aryl hydrocarbon receptor interacting protein like 1, Aryl-hydrocarbon-interacting protein-like 1, LCA4, MGC25485, OTTHUMP00000128207, OTTMUSP00000006382, RP23-401C17.1.

Background: The inherited blindness associated protein, aryl hydrocarbon receptor interacting protein-like 1 (AIPL1), interacts with the cell cycle regulator protein NUB1. AIPL1 is crucial for protein folding and stabilization, as well as for protein trafficking. It localizes to the nucleus or cytoplasm and is highly expressed in the pineal gland and the retina. In the retina, AIPL1 is expressed in both developing cone and rod photoreceptors, but it is restricted to rod photoreceptors in the adult human retina. Defects in the gene encoding for AIPL1 can cause Leber congenital amaurosis type IV, an early-onset, inherited autosomal recessive disorder that results in childhood blindness.

Gene ID: 23746