PBX2 antibody (AA 265-370) (Biotin)

Catalog No. ABIN1700716

Product Details anti-PBX2 Antibody (Biotin)

Target: PBX2 (Pre-B-Cell Leukemia Homeobox Protein 2 (PBX2))

Binding Specificity: AA 265-370

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PBX2 antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Pig,Horse,Chicken,Rabbit,Zebrafish

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human PBX2

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for PBX2

Target: PBX2 (Pre-B-Cell Leukemia Homeobox Protein 2 (PBX2))

Alternative Name: PBX2 (PBX2 Products)

Synonyms: G17 antibody, HOX12 antibody, PBX2MHC antibody, AU043397 antibody, pbxy antibody, wu:fb73g03 antibody, hox12 antibody, pbx2mhc antibody, PBX2P1 antibody, PBX homeobox 2 antibody, pre B cell leukemia homeobox 2 antibody, pre-B-cell leukemia homeobox 2 antibody, pre-B-cell leukemia homeobox 2 L homeolog antibody, PBX2 antibody, Pbx2 antibody, pbx2 antibody, pbx2.L antibody

Background:

Synonyms: G17, Homeobox protein PBX2, HOX12, PBX2MHC, pre-B-cell leukemia homeobox 2, pre-B-cell leukemia transcription factor 2, Protein G17, PBX2_HUMAN.

Background: Pbx 1, 2, 3 and 4 are members of the TALE (three amino acid loop extension) family of homeodomain-containing proteins. Human pre-B cell acute leukemias are frequently associated with a t(1,19)(q23,p13.3) chromosomal rearrangement, which creates a chimeric gene encoding a fusion between the E2A and Pbx 1 gene products. Pbx 2 and Pbx 3 share 92 % and 94 % respective identities with Pbx 1 over a 266 amino acid region flanking their homeobox domains, while all three proteins are quite divergent at their amino- and carboxy-termini. Two forms of Pbx 1 and Pbx 3 each differ primarily in their carboxy-termini and result from alternative mRNA splicing. Unlike other homeotic selector genes which are expressed transiently during development and differentiation, Pbx gene transcripts are ubiquitously expressed in both fetal and adult tissues and cell lines. Additionally, Pbx 2 and Pbx 3 transcripts are detected in lymphoid cells, which do not express Pbx 1. Pbx 4 expression is confined to the testis, especially to spermatocytes in the pachytene stage of the first meiotic prophase.

Gene ID: 5089

Pathways: Skeletal Muscle Fiber Development