MIB1 antibody (AA 101-200) (Biotin)
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- Target See all MIB1 Antibodies
- MIB1 (Mindbomb E3 Ubiquitin Protein Ligase 1 (MIB1))
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Binding Specificity
- AA 101-200
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This MIB1 antibody is conjugated to Biotin
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Application
- ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Predicted Reactivity
- Human,Mouse,Rat,Dog,Cow,Chicken,Rabbit
- Purification
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human Mib1/Mindbomb
- Isotype
- IgG
- Top Product
- Discover our top product MIB1 Primary Antibody
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- Application Notes
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IHC-P 1:200-400
IHC-F 1:100-500 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C for 12 months.
- Expiry Date
- 12 months
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- Target
- MIB1 (Mindbomb E3 Ubiquitin Protein Ligase 1 (MIB1))
- Abstract
- MIB1 Products
- Synonyms
- DIP-1 antibody, DIP1 antibody, LVNC7 antibody, MIB antibody, ZZANK2 antibody, ZZZ6 antibody, E430019M12Rik antibody, Mib antibody, mKIAA1323 antibody, dip-1 antibody, mib antibody, mindbomb antibody, cg5841 antibody, chunp6889 antibody, fe47f05 antibody, im:7148100 antibody, mib1 antibody, wu:fe47f05 antibody, CG5841 antibody, D-mib antibody, D-mib1 antibody, Dmel\CG5841 antibody, Dmib antibody, MIB1 antibody, Mib1 antibody, dmib1 antibody, l(3)72CDa antibody, l(3)72Db antibody, mib1/2 antibody, mind-bomb antibody, mindbomb E3 ubiquitin protein ligase 1 antibody, mindbomb E3 ubiquitin protein ligase 1 L homeolog antibody, mind bomb 1 antibody, MIB1 antibody, Mib1 antibody, mib1.L antibody, mib1 antibody
- Background
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Synonyms: DAPK-interacting protein 1, Dip 1, DIP-1, Dip1, E3 ubiquitin protein ligase MIB 1, E3 ubiquitin protein ligase MIB1, E3 ubiquitin-protein ligase mib1, mib1, MIB1_HUMAN, Mind bomb homolog 1, Zinc finger ZZ type with ankyrin repeat domain protein 2.
Background: MIB1 is a 1006 amino acid E3 ubiquitin ligase that activates the Notch ligand, Delta. MIB1 ubiquinates Delta by binding to its intracellular domain, leading to the endocytosis and eventual degradation of the Delta receptor, which, paradoxically, results in the up-regulation of receptor activity and enhances Notch signaling. MIB1 also interacts with DAPK, a protein that plays an important role in the regulation of apoptosis. Ubiquination of DAPK leads to inhibition of caspase-dependent apoptosis, therefore it is likely that overexpression of MIB1 can lead to tumor growth. Although it seems to be widely expressed at low levels, MIB1 is expressed at highest concentrations in the CNS and ovary. Both DAPK and MIB1 are overexpressed in epileptic brain tissue, suggesting that they probably cooperate as regulators of neuronal death in epilepsy.
- Gene ID
- 57534
- Pathways
- SARS-CoV-2 Protein Interactome, The Global Phosphorylation Landscape of SARS-CoV-2 Infection
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