BTBD14A antibody (AA 401-500) (Biotin)

Catalog No. ABIN1700539

Product Details anti-BTBD14A Antibody (Biotin)

Target: BTBD14A (BTB (POZ) Domain Containing 14A (BTBD14A))

Binding Specificity: AA 401-500

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BTBD14A antibody is conjugated to Biotin

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Sheep,Horse,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human BTBD14A

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for BTBD14A

Target: BTBD14A (BTB (POZ) Domain Containing 14A (BTBD14A))

Alternative Name: BTBD14A (BTBD14A Products)

Synonyms: NACC2 antibody, BTBD14A antibody, BEND9 antibody, BTBD14 antibody, BTBD31 antibody, Btbd14a antibody, 0610020I02Rik antibody, AI448087 antibody, C030048H19Rik antibody, NACC family member 2 antibody, nucleus accumbens-associated protein 2-like antibody, nucleus accumbens associated 2, BEN and BTB (POZ) domain containing antibody, NACC2 antibody, LOC100354269 antibody, Nacc2 antibody

Background:

Synonyms: BTB POZ domain containing 14A, BTB domain containing 14A, BTB/POZ domain containing protein 14A, BTB/POZ domain-containing protein 14A, BTBD 14A, BTBD14, NAC-2, NACC2, NACC2_HUMAN, Nucleus accumbens-associated protein 2.

Background: BTBD14A is a 587 amino acid protein that contains one BTB/POZ domain. The BTB/POZ domain mediates homomeric and heteromeric POZ-POZ interactions and is common to transcriptional regulators involved in chromatin modeling. In several BTB/POZ containing proteins, including BCL-6 and the promyelocytic leukemia zinc-finger (PLZF) oncoprotein, this domain interacts with the SMRT/N-CoR-mSin3A HDAC complex and is directly involved in repressing and silencing gene transcription. When this domain is deleted, as with the oncogenic PLZF-RAR chimera of promyelocytic leukemias, this transcriptional repression is attenuated. This suggests that BTBD14A may play a role in transcription regulation.

Gene ID: 54813

Pathways: Positive Regulation of Response to DNA Damage Stimulus