Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

SUMO2/3 antibody (AA 21-95) (Biotin)

SUMO2/3 Reactivity: Human WB, ELISA, IHC (p), IHC (fro) Host: Rabbit Polyclonal Biotin
Catalog No. ABIN1700509
  • Target See all SUMO2/3 products
    SUMO2/3 (Small Ubiquitin Related Modifier 2/3 (SUMO2/3))
    Binding Specificity
    • 15
    • 7
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 21-95
    Reactivity
    • 48
    • 14
    • 14
    • 1
    • 1
    • 1
    Human
    Host
    • 37
    • 10
    • 1
    Rabbit
    Clonality
    • 29
    • 19
    Polyclonal
    Conjugate
    • 15
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SUMO2/3 antibody is conjugated to Biotin
    Application
    • 41
    • 24
    • 15
    • 14
    • 14
    • 13
    • 10
    • 6
    • 3
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Cross-Reactivity
    Human
    Predicted Reactivity
    Mouse,Rat,Cow,Horse,Chicken,Rabbit,Zebrafish
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human Sumo 2+3
    Isotype
    IgG
  • Application Notes
    WB 1:300-5000
    IHC-P 1:200-400
    IHC-F 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C for 12 months.
    Expiry Date
    12 months
  • Target
    SUMO2/3 (Small Ubiquitin Related Modifier 2/3 (SUMO2/3))
    Alternative Name
    Sumo 2+3 (SUMO2/3 Products)
    Synonyms
    SUMO2 antibody, small ubiquitin-like modifier 2 antibody, SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)-like antibody, small ubiquitin-related modifier 2 antibody, SUMO2 antibody, LOC711990 antibody, LOC714892 antibody
    Background

    Synonyms: HSMT3, MGC117191, OTTHUMP00000115275, OTTHUMP00000115276, OTTHUMP00000115277, Sentrin 2, Small ubiquitin like modier 2, Small ubiquitin like modier protein 3, Small ubiquitin related modier 2, Small ubiquitin related modier 3, SMT3 A, SMT3 B, SMT3 H1, SMT3 H2, SMT3 homolog 1, SMT3 homolog 2, SMT3 homolog, SMT3 suppressor of m two 3 homolog 1, SMT3 suppressor of m two 3 homolog 2 S. cerevisiae, SMT3 suppressor of m two 3 homolog 2, SMT3 suppressor of m two 3 homolog 3 S. cerevisiae, SMT3 suppressor of m two 3 homolog 3, SMT3A, SMT3B, SMT3H1, SMT3H2, Sumo 2, Sumo 3, Sumo2, Sumo3, Suppressor of m two 3 homolog 2, Suppressor of m two 3 homolog 3, Ubiquitin like protein SMT3A, Ubiquitin like protein SMT3B, SUMO2_HUMAN, SUMO3_HUMAN.

    Background: The small ubiquitin-related modifier (SUMO) proteins, which include SUMO-1, SUMO-2 and SUMO-3, belong to the ubiquitin-like protein family. Like ubiquitin, the SUMO proteins are synthesized as precursor proteins that undergo processing before conjugation to target proteins. Also, both utilize the E1, E2, and E3 cascade enzymes for conjugation. However, SUMO and ubiquitin differ with respect to targeting. Ubiquitination predominantly targets proteins for degradation, whereas sumoylation targets proteins to a variety of cellular processing, including nuclear transport, transcriptional regulation, apoptosis and protein stability. The unconjugated SUMO-1, SUMO-2 and SUMO-3 proteins localize to the nuclear membrane, nuclear bodies and cytoplasm, respectively. SUMO-1 utilizes Ubc9 for conjugation to several target proteins, which include IkBa, MDM2, p53, PML and Ran GAP1. SUMO-2 and SUMO-3 contribute to a greater percentage of protein modification than does SUMO-1, and unlike SUMO-1, they can form polymeric chains. In addition, SUMO-3 regulates b-Amyloid generation and may be critical in the onset or progression of Alzheimer?s disease.

You are here:
Support