FHOD1 antibody (pThr1141) (Biotin)

Catalog No. ABIN1700461

Product Details anti-FHOD1 Antibody (Biotin)

Target: FHOD1 (Formin Homology 2 Domain Containing 1 (FHOD1))

Binding Specificity: pThr1141

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FHOD1 antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Human, Rat

Predicted Reactivity: Mouse,Dog,Cow,Pig,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human FHOD1 around the phosphorylation site of Thr1141

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for FHOD1

Target: FHOD1 (Formin Homology 2 Domain Containing 1 (FHOD1))

Alternative Name: FHOD1 (FHOD1 Products)

Synonyms: FHOS antibody, BC017144 antibody, FHOS1 antibody, formin homology 2 domain containing 1 antibody, FHOD1 antibody, Fhod1 antibody

Background:

Synonyms: FHOD1 phospho T1141, p-FHOD1 phospho T1141, FH1/FH2 domain containing protein, FH1/FH2 domain-containing protein 1, Fhod1, FHOD1_HUMAN, FHOS, FHOS1, Formin homolog overexpressed in spleen 1, Formin homology 2 domain containing 1, Formin homology 2 domain containing protein 1, Formin homology 2 domain-containing protein 1.

Background: The limb deformity (ld) locus influences normal limb development and gives rise to alternative mRNAs that can translate into a family of protein products known as formins. Formins play a crucial role in cytoskeletal reorganization by influencing actin filament assembly. The temporal genetic hierarchy influencing normal limb development can deregulate and mediate mammalian developmental syndromes. FHOD1 induces the formation of and associates with bundled actin stress fibers in response to the activity of the Rho-ROCK cascade. It influences several cellular activities including cell migration, cytoskeletal arrangement, signal transduction and gene expression.

Gene ID: 29109