GEMIN6 antibody (AA 21-120) (Biotin)

Catalog No. ABIN1700311

Product Details anti-GEMIN6 Antibody (Biotin)

Target: GEMIN6 (Gem (Nuclear Organelle) Associated Protein 6 (GEMIN6))

Binding Specificity: AA 21-120

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GEMIN6 antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Cross-Reactivity: Human, Rat

Predicted Reactivity: Mouse,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Gemin 6

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for GEMIN6

Target: GEMIN6 (Gem (Nuclear Organelle) Associated Protein 6 (GEMIN6))

Alternative Name: Gemin 6 (GEMIN6 Products)

Synonyms: 2610019B15Rik antibody, 2810470M17Rik antibody, gemin6 antibody, gem nuclear organelle associated protein 6 antibody, gem (nuclear organelle) associated protein 6 antibody, gem nuclear organelle associated protein 6 S homeolog antibody, GEMIN6 antibody, Gemin6 antibody, gemin6.S antibody

Background:

Synonyms: FLJ23459, Gemin6, Gemin-6, Gem nuclear organelle associated protein 6, Gem-associated protein 6, GEMI6, GEMI6_HUMAN, Gemin-6, GEMIN6, SIP2.

Background: Spinal muscular atrophy (SMA) is an autosomal recessive neurodegenerative disease characterized by loss of motor neurons in the spinal cord. SMA is caused by deletion or loss-of-function mutations in the SMN (Survival of Motor Neuron) gene. Gemin6, the protein product of human chromosome 2p22.2, associates directly with SMN and is a part of the SMN complex containing Gemin2, Gemin3, Gemin4 and Gemin5 as well as several spliceosomal snRNP proteins. The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing of the nucleus. The SMN complex is found in both the cytoplasm and the nucleus. The nuclear form is concentrated in subnuclear bodies called gems (Gemini of the coiled bodies).

Gene ID: 79833

Pathways: Ribonucleoprotein Complex Subunit Organization