GPR17 antibody (AA 2-100) (Biotin)

Catalog No. ABIN1700293

Product Details anti-GPR17 Antibody (Biotin)

Target: GPR17 (G Protein-Coupled Receptor 17 (GPR17))

Binding Specificity: AA 2-100

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GPR17 antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Predicted Reactivity: Human

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human G protein coupled receptor 17

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for GPR17

Target: GPR17 (G Protein-Coupled Receptor 17 (GPR17))

Alternative Name: GPR17 (GPR17 Products)

Synonyms: GPR17 antibody, AI853548 antibody, G protein-coupled receptor 17 antibody, GPR17 antibody, Gpr17 antibody

Background:

Synonyms: DKFZp686M18273, G protein coupled receptor 17, G-protein coupled receptor 17, GPR 17, Gpr17, GPR17_HUMAN, P2Y like receptor, P2Y-like receptor, Probable P2Y purinoceptor GPR 17, Probable P2Y purinoceptor GPR17, R12, UDP/CysLT receptor, Uracil nucleotide/cysteinyl leukotriene receptor, GPCR GPR17.

Background: G protein-coupled receptor 17, GPR17, also known as uracil nucleotide/cysteinyl leukotriene receptor or P2Y-like receptor (P2YL), is a 367 amino acid member of the G-protein coupled receptor 1 family of proteins. While GPR17 is expressed in kidney, heart and umbilical vein endothelial cells, it is expressed in the highest levels in the brain. Upon brain injury, the extracellular concentrations of nucleotides and cysteinyl leukotrienes (CysLTs), two families of endogenous signaling molecules, increase significantly at the site of damage. In some neurons, GPR17, a membrane receptor for uracil nucleotide and CysLTs, is upregulated as well, infiltrating the lesioned area. GPR17 is thought to play a role in mediating neuronal death, remodeling brain circuitries by microglia and initiating remyelination in damaged neurons. Two named isoforms of GPR17 exist as a result of alternative splicing events.

Gene ID: 2840

UniProt: Q13304