Cadherin 12 antibody (AA 291-390) (Biotin)

Catalog No. ABIN1700242

Product Details anti-Cadherin 12 Antibody (Biotin)

Target: Cadherin 12

Binding Specificity: AA 291-390

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Cadherin 12 antibody is conjugated to Biotin

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Rat

Predicted Reactivity: Human,Mouse,Dog,Cow,Sheep,Pig,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CDH12

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for Cadherin 12

Target: Cadherin 12

Alternative Name: CDH12 (Cadherin 12 Products)

Synonyms: CDHB antibody, Cdhb antibody, RGD1566350 antibody, cdh12 antibody, cadherin 12 antibody, cadherin-12 antibody, CDH12 antibody, Cdh12 antibody, LOC570372 antibody

Background:

Synonyms: Br cadherin, BR-cadherin, Brain cadherin, CAD12_HUMAN, cadherin 12 N cadherin 2, Cadherin 12, Cadherin 12 precursor, Cadherin 12 type 2 N cadherin 2, Cadherin 12 type 2, Cadherin neural type 2, Cadherin-12, CDH12, CDHB, FLJ34857, N cadherin 2, N-cadherin 2, Neural type cadherin 2, Neuronal cadherin 2.

Background: The cadherins are a family of Ca++-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of tissue structure and morpho-genesis (1-4). Cadherins each contain a large extracellular domain at the amino terminus, which is characterized by a series of five homologous repeats, the most distal of which is thought to be responsible for binding specificity (5,6). The relatively short carboxy terminal, intracellular domain interacts with a variety of cytoplasmic proteins, including catenin b, to regulate cadherin function (7). BR-cadherin (for brain-cadherin, also designated cadherin-12 or N-cadherin 2) is expressed specifically in neurons in the central nervous system and is thought to be involved in neuronal development (8).