TRIM22 antibody (AA 231-330) (Biotin)

Catalog No. ABIN1700082

Product Details anti-TRIM22 Antibody (Biotin)

Target: TRIM22 (Tripartite Motif Containing 22 (TRIM22))

Binding Specificity: AA 231-330

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRIM22 antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Human

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Trim22

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for TRIM22

Target: TRIM22 (Tripartite Motif Containing 22 (TRIM22))

Alternative Name: Trim22/Staf-50 (TRIM22 Products)

Synonyms: GPSTAF50 antibody, RNF94 antibody, STAF50 antibody, tripartite motif containing 22 antibody, TRIM22 antibody

Background:

Synonyms: 50 kDa stimulated trans acting factor, RING finger protein 94, RNF94, Staf 50, STAF50, Stimulated trans acting factor 50 kDa, Stimulated Trans Acting Factor homolog of Mouse Rpt 1 gene, Trim22, Tripartite binding mot 22, Tripartite mot containing protein 22, TTRIM22RIM22, TRI22_HUMAN.

Background: The tripartite motif (TRIM) family of proteins are characterized by a conserved TRIM domain that includes a coiled-coil region, a B-box type zinc finger, one RING finger and three zinc-binding domains. Staf-50 (50 kDa-stimulated trans-acting factor), also known as TRIM22 (tripartite motif-containing 22), RNF94 or GPSTAF50, is a 498 amino acid cytoplasmic protein that belongs to the TRIM family and, characteristic of TRIM family members, contains one RING-type zinc finger, one B box-type zinc finger and one SPRY domain. Induced by IFN-å, and IFN-, Staf-50 is strongly expressed in ovary, spleen, thymus and peripheral blood leukocytes where it is thought to mediate the antiviral effects of IFN proteins. Additionally, Staf-50 is present in leukemic cells, suggesting a role in cancer formation and metastasis. Staf-50 exists as two alternatively spliced isoforms which are encoded by a gene that maps to human chromosome 11.

Gene ID: 10346