TOM1L1 antibody (AA 1-100) (Biotin)

Catalog No. ABIN1700080

Product Details anti-TOM1L1 Antibody (Biotin)

Target: TOM1L1 (Target of Myb1 (Chicken)-Like 1 (TOM1L1))

Binding Specificity: AA 1-100

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TOM1L1 antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Predicted Reactivity: Human,Cow,Sheep,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human TOM1L1

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for TOM1L1

Target: TOM1L1 (Target of Myb1 (Chicken)-Like 1 (TOM1L1))

Alternative Name: TOM1L1 (TOM1L1 Products)

Synonyms: MGC52738 antibody, srcasm antibody, TOM1L1 antibody, OK/KNS-CL.3 antibody, SRCASM antibody, RGD1562626 antibody, Srcasm antibody, 2310045L10Rik antibody, C80573 antibody, target of myb1 like 1 membrane trafficking protein L homeolog antibody, target of myb1 like 1 membrane trafficking protein antibody, target of myb1-like 1 (chicken) antibody, tom1l1.L antibody, TOM1L1 antibody, tom1l1 antibody, Tom1l1 antibody

Background:

Synonyms: OK/KNS CL.3, Src activating and signaling molecule, Src activating and signaling molecule protein, Src-activating and signaling molecule protein, SRCASM, Target of Myb like protein 1, Target of Myb-like protein 1, Target of myb1 chicken homolog like 1, Target of myb1 chicken like 1, Target of myb1 like 1, TM1L1_HUMAN, TOM1 L1, TOM1 like protein 1, TOM1-like protein 1, TOM1L1, TOM1L1 protein.

Background: Tom1L-1 is a 476 amino acid Golgi apparatus protein belonging to the TOM1 family and is a member of the multivesicular body (MVB) sorting machinery. Containing a GAT domain and a VHS domain, Tom1L-1 interacts with Fyn, GRB2, PI 3-kinase p85?and various signaling proteins when phosphorylated. GAT domain of Tom1L1 binds ubiquitin, suggesting participation in the sorting of ubiquitinated proteins into MVBs. Tom1L-1 may act as an adapter protein involved in signaling pathways and may promote Fyn activation, possibly by disrupting intramolecular SH3-dependent interactions. As an interactor and a substrate of Src tyrosine kinases (SFK), Tom1L1 is considered a novel mechanism involved in negative regulation of SFK mitogenic and transforming signals. Tom1L1 modulates SFK partitioning at the plasma membrane and downregulates Src kinases in an endosomal-dependent manner. It is suggested that Tom1L-1 functions as an anti-oncogene by inhibiting the formation of squamous cell carcinomas in skin.