EXOSC10 antibody (AA 41-140) (AbBy Fluor® 647)
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- Target See all EXOSC10 Antibodies
- EXOSC10 (Exosome Component 10 (EXOSC10))
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Binding Specificity
- AA 41-140
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Reactivity
- Human, Mouse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This EXOSC10 antibody is conjugated to AbBy Fluor® 647
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Application
- Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Cross-Reactivity
- Human, Mouse
- Predicted Reactivity
- Rat,Dog,Cow,Sheep,Pig,Horse
- Purification
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human EXOSC10/PMSCL2
- Isotype
- IgG
- Top Product
- Discover our top product EXOSC10 Primary Antibody
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- Application Notes
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Expiry Date
- 12 months
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- Target
- EXOSC10 (Exosome Component 10 (EXOSC10))
- Alternative Name
- EXOSC10/PMSCL2 (EXOSC10 Products)
- Synonyms
- Pmscl2 antibody, zgc:55695 antibody, pm-scl antibody, pm/scl-100 antibody, pmscl antibody, pmscl2 antibody, rrp6 antibody, rrp6p antibody, EXOSC10 antibody, 201.t00018 antibody, 21.m02990 antibody, DDBDRAFT_0203581 antibody, DDBDRAFT_0233752 antibody, DDB_0203581 antibody, DDB_0233752 antibody, PM-Scl antibody, PM/Scl-100 antibody, PMSCL antibody, PMSCL2 antibody, RRP6 antibody, Rrp6p antibody, p2 antibody, p3 antibody, p4 antibody, exosome component 10 antibody, 3'-5' exonuclease antibody, exosome component 10 L homeolog antibody, exosc10 antibody, EXOSC10 antibody, EHI_021400 antibody, BBOV_IV002650 antibody, CpipJ_CPIJ003896 antibody, CMU_031760 antibody, Tsp_05247 antibody, exosc10.L antibody, Exosc10 antibody
- Background
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Synonyms: Autoantigen PM/Scl 2, Exosc10, Exosome component 10, EXOSX_HUMAN, P100 polymyositis scleroderma overlap syndrome associated autoantigen, P100 polymyositis-scleroderma overlap syndrome-associated autoantigen, p2, p3, p4, PM Scl, PM/Scl 100, PM/Scl-100, PMSCL, PMSCL2, Polymyositis/scleroderma autoantigen 100 kDa, Polymyositis/scleroderma autoantigen 2 100 kDa, Polymyositis/scleroderma autoantigen 2, RRP6, Rrp6p.
Background: The exosome is a multi-subunit complex composed of several highly conserved proteins, some of which are 3? to 5? exoribonucleases. The complex is involved in a variety of cellular processes and is responsible for degrading unstable mRNAs that contain AU-rich (ARE) elements in their untranslated 3? region. EXOSC10, also known as PMSCL, PMSCL2, p2, p3, p4, RRP6, Rrp6p, PM-Scl, or PM/Scl-100, is an 885 amino acid protein that contains one HRDC domain and one 3?-5? enonuclease domain. Localized to both the cytoplasm and the nucleus, EXOSC10 is part of the post-splicing exosome complex and is involved in mRNA surveillance, mRNA nuclear export and nonsense-mediated decay of mRNAs containing premature stop codons. against EXOSC10 have been found in patients with scleroderma and/or polymyositis (chronic diseases of the skin and muscle, respectively), suggesting that EXOSC10 may be involved in the pathogenesis of these diseases. Two isoforms of EXOSC10 exist due to alternative splicing events.
- Gene ID
- 5394
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