EXTL3 antibody (AA 351-450) (AbBy Fluor® 647)

Catalog No. ABIN1699125

Product Details anti-EXTL3 Antibody (AbBy Fluor® 647)

Target: EXTL3 (Exostoses (Multiple)-Like 3 (EXTL3))

Binding Specificity: AA 351-450

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EXTL3 antibody is conjugated to AbBy Fluor® 647

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Cross-Reactivity: Rat

Predicted Reactivity: Human,Mouse,Dog,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human EXTL3

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for EXTL3

Target: EXTL3 (Exostoses (Multiple)-Like 3 (EXTL3))

Alternative Name: EXTL3 (EXTL3 Products)

Synonyms: BcDNA:LD21192 antibody, Botv antibody, CG15110 antibody, DEXT3 antibody, DEXTL3 antibody, Dextl3 antibody, Dmel\\CG15110 antibody, Extl3 antibody, 2900009G18Rik antibody, AU040105 antibody, Ext1l antibody, mKIAA0519 antibody, BOTV antibody, EXTL1L antibody, EXTR1 antibody, REGR antibody, RPR antibody, Regr antibody, brother of tout-velu antibody, exostoses (multiple)-like 3 antibody, exostosin like glycosyltransferase 3 antibody, exostosin-like glycosyltransferase 3 antibody, botv antibody, Extl3 antibody, EXTL3 antibody

Background:

Synonyms: botv, DKFZp686C2342, Exostoses multiple-like 3, Exostoses-like 3, Exostosin-like 3, EXT-related protein 1, EXTL1L, EXTL3, EXTL3_HUMAN, EXTR1, Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferas, Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase, Hereditary multiple exostoses gene isolog, KIAA0519, Multiple exostosis-like protein 3, Putative tumor suppressor protein EXTL3, REG, Reg receptor, REGR, RPR.

Background: EXTL3 is a member of the EXT (hereditary multiple exostosin) gene family of tumor suppressors encoding glycosyltransferases involved in heparan sulfate (HS) biosynthesis. Within this family, the C-terminus is conserved between all members from C. elegans to vertebrates. EXTL3 is a ubiquitously expressed, developmentally regulated, single-pass type II membrane protein that localizes to the endoplasmic reticulum membrane. EXTL3 adds N-acetylglucosamine (GlcNAc) to the polysaccharide-protein linkage region and to the growing HS chain suggesting that it plays a role in both the initiation and elongation of HS chains. In addition, EXTL3 may act as a Reg receptor, binding Reg via its N-terminus.

Gene ID: 2137

Pathways: Glycosaminoglycan Metabolic Process, ER-Nucleus Signaling