BOP1 antibody (AA 201-300) (AbBy Fluor® 647)

Catalog No. ABIN1698802

Product Details anti-BOP1 Antibody (AbBy Fluor® 647)

Target: BOP1 (Block of Proliferation 1 (BOP1))

Binding Specificity: AA 201-300

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BOP1 antibody is conjugated to AbBy Fluor® 647

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Cross-Reactivity: Mouse

Predicted Reactivity: Human,Rat,Dog,Cow,Sheep,Pig,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human BOP1

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for BOP1

Target: BOP1 (Block of Proliferation 1 (BOP1))

Alternative Name: BOP1 (BOP1 Products)

Synonyms: AU020183 antibody, AW146150 antibody, D18861 antibody, Erb1p antibody, Kiaa0124 antibody, mKIAA0124 antibody, bop1-B antibody, id:ibd1283 antibody, si:ch211-251g8.2 antibody, si:ch211-251g8.4 antibody, zgc:154135 antibody, MCG5033 antibody, bop1-a antibody, bop1-b antibody, Block of proliferation 1 antibody, block of proliferation 1 antibody, block of proliferation 1 L homeolog antibody, block of proliferation 1 S homeolog antibody, GL50803_8035 antibody, Mbre_bop1 antibody, Bop1 antibody, bop1.L antibody, BOP1 antibody, bop1 antibody, bop1.S antibody

Background:

Synonyms: AU020183, AW146150, Block of proliferation 1, Block of proliferation 1 protein, Bop1, Bop1 block of proliferation 1, BOP1_HUMAN, D18861, Erb1p, Kiaa0124, MGC109114, mKIAA0124, Ribosome biogenesis protein BOP1.

Background: Predominantly localized to the nucleolus, BOP1 (Block of proliferation 1 protein) is a 746 amino acid highly conserved non-ribosomal protein that is involved in ribosome biogenesis. Truncation of the amino terminus of BOP1 leads to cell growth arrest in the G1 phase and specific inhibition of 28S and 5.8S rRNA synthesis, as well as a deficit in the cytosolic 60S ribosomal subunit. This suggests that BOP1 is involved in the formation of mature rRNAs and in the biogenesis of the 60S ribosomal subunit. BOP1 physically interacts with pescadillo (a protein involved in cell proliferation) and enables efficient incorporation of pescadillo into the nucleolar preribosomal complexes, thereby affecting rRNA maturation and the cell cycle. The BOP1-pescadillo complex is also necessary for biogenesis of 60S ribosomal subunits. Deregulation of BOP1 may lead to colorectal tumorigenesis.

Gene ID: 23246