CTBS antibody (AA 1-100) (AbBy Fluor® 647)

Catalog No. ABIN1698439

Product Details anti-CTBS Antibody (AbBy Fluor® 647)

Target: CTBS (Chitobiase, Di-N-Acetyl (CTBS))

Binding Specificity: AA 1-100

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CTBS antibody is conjugated to AbBy Fluor® 647

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Cross-Reactivity: Mouse

Predicted Reactivity: Human,Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CTBS

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for CTBS

Target: CTBS (Chitobiase, Di-N-Acetyl (CTBS))

Alternative Name: CTBS (CTBS Products)

Synonyms: CTB antibody, 2210401K11Rik antibody, chitobiase antibody, chitobiase, di-N-acetyl- antibody, CTBS antibody, Ctbs antibody

Background:

Synonyms: Chitobiase di N acetyl, CTB, Di N acetylchitobiase, OTTHUMP00000011570, DIAC_HUMAN.

Background: CTBS is an evolutionarily conserved member of the glycosyl hydrolase 18 family of proteins. Localizing to the lysosome, CTBS plays a role in the degradation of asparagine-linked (Asn-linked) glycoproteins. Glycoproteins are translocated to lysosomes via endocytosis or autophagy where they are broken down by proteases and glycosidases. The catabolism of glycoproteins is an important step in the regular turnover of cellular contents and in maintaining the homeostasis of glycosylation. CTBS functions as a glycosidase that cleaves the reducing end GlcNAc from the core chitobiase unit of oligosaccharides. Before this reaction can occur, AGA (the lysosomal glycosylasparaginase) must first remove the Asn from the Asn-linked glycoprotein to expose the reducing end GlcNAc, thereby allowing CTBS to access the exposed moiety.

Gene ID: 1486