FANCM antibody (AA 831-930) (AbBy Fluor® 555)
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- Target See all FANCM Antibodies
- FANCM (Fanconi Anemia Complementation Group M (FANCM))
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Binding Specificity
- AA 831-930
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This FANCM antibody is conjugated to AbBy Fluor® 555
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Application
- Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Predicted Reactivity
- Human
- Purification
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human FANCM
- Isotype
- IgG
- Top Product
- Discover our top product FANCM Primary Antibody
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- Application Notes
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Expiry Date
- 12 months
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- Target
- FANCM (Fanconi Anemia Complementation Group M (FANCM))
- Alternative Name
- FANCM (FANCM Products)
- Synonyms
- FAAP250 antibody, KIAA1596 antibody, AI427100 antibody, C730036B14Rik antibody, D12Ertd364e antibody, Fanconi anemia complementation group M antibody, hypothetical protein antibody, Fanconi anemia, complementation group M antibody, FANCM antibody, PGTG_17854 antibody, Fancm antibody
- Background
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Synonyms: FAAP250, Fanconi anemia group M protein, Protein Hef ortholog,
Background: Fanconi anemia (FA) is an autosomal recessive disorder characterized by bone marrow failure, birth defects and chromosomal instability. At the cellular level, FA is characterized by spontaneous chromosomal breakage and a unique hypersensitivity to DNA cross-linking agents. The thirteen FA proteins that have been characterized are important for regulating chromosomal stability and genome surveillance. Eight of these proteins, namely FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL and FANCM, comprise the FA core complex, which catalyzes a key reaction in DNA repair: the monoubiquitination of FANCD2. FANCM (Fanconi anemia, complementation group M) is a member of the DEAD-box helicase family of proteins and contains a DEAH helicase domain and a nuclease domain. Localizing to chromatin fractions, FANCM is phosphorylated in a cell cycle-dependent manner and is believed to function as an anchor, recruiting the FA core complex to chromatin. Mutations in the gene encoding FANCM can lead to Fanconi anemia.
- Gene ID
- 57697
- Pathways
- DNA Damage Repair
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