Clca3 antibody (AbBy Fluor® 488)

Catalog No. ABIN1696188

Product Details anti-Clca3 Antibody (AbBy Fluor® 488)

Target: Clca3 (CLCA3) (Epithelial Chloride Channel Protein (CLCA3))

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Clca3 antibody is conjugated to AbBy Fluor® 488

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Predicted Reactivity: Mouse,Rat,Dog

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from mouse CLCA3

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for Clca3

Target: Clca3 (CLCA3) (Epithelial Chloride Channel Protein (CLCA3))

Alternative Name: Clca3 (CLCA3 Products)

Synonyms: calcium-activated chloride channel antibody, LOC784768 antibody

Background:

Synonyms: Calcium activated chloride channel 3, Calcium-activated chloride channel regulator family member 3, Chloride channel accessory 3 pseudogene, chloride channel calcium activated 3, Chloride channel calcium activated family member 3, Clca1, Clca2, CLCA3P, Gob 5, Gob-5, Gob5, hCLCA3, mCLCA3, MGC143984, MGC143985.

Background: The calcium-activated chloride channel (CLCA) protein family, which includes the human homologs CLCA1 and CLCA2, display distinct tissue distribution patterns. CLCA1 is expressed as a precursor protein that is processed into two cell surface associated subunits and a group of proteins. CLCA1 is upregulated by interleukin-9 and regulates the expression of mucins. CLCA1 may provide a therapeutic target to control mucus overproduction in airway disease patients with cystic fibrosis. CLCA2 expression is downregulated in breast cancer, therefore CLCA2 is thought to act as a tumor suppressor in normal cells. CLCA3 (known as Clca3 in mouse) is a structurally divergent member of the CLCA family that does not function as a channel protein. CLCA4 is a CLCA member that is expressed in human rectal mucosa, CLCA5 shows strong expression in eye and spleen, and CLCA6 is primarily expressed in intestine and stomach.