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TLE4 antibody (AA 681-773) (AbBy Fluor® 488)

TLE4 Reactivity: Human WB, IF (cc), IF (p) Host: Rabbit Polyclonal AbBy Fluor® 488
Catalog No. ABIN1695943
  • Target See all TLE4 Antibodies
    TLE4 (Transducin-like Enhancer Protein 4 (TLE4))
    Binding Specificity
    • 14
    • 10
    • 8
    • 6
    • 5
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    AA 681-773
    Reactivity
    • 57
    • 19
    • 18
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 53
    • 5
    Rabbit
    Clonality
    • 55
    • 3
    Polyclonal
    Conjugate
    • 24
    • 5
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This TLE4 antibody is conjugated to AbBy Fluor® 488
    Application
    • 46
    • 25
    • 12
    • 12
    • 9
    • 7
    • 4
    • 3
    • 2
    • 2
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Predicted Reactivity
    Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human TLE4
    Isotype
    IgG
    Top Product
    Discover our top product TLE4 Primary Antibody
  • Application Notes
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Expiry Date
    12 months
  • Target
    TLE4 (Transducin-like Enhancer Protein 4 (TLE4))
    Alternative Name
    TLE4 (TLE4 Products)
    Synonyms
    TLE4 antibody, NV17443 antibody, BCE-1 antibody, BCE1 antibody, E(spI) antibody, ESG antibody, ESG4 antibody, GRG4 antibody, Esp2 antibody, Grg4 antibody, XGrg-4 antibody, XTCF-4 antibody, Xgrg4 antibody, Xtle4 antibody, esg4 antibody, grg4 antibody, gro antibody, 5730411M05Rik antibody, AA792082 antibody, Bce-1 antibody, Bce1 antibody, ESTM13 antibody, ESTM14 antibody, X83332 antibody, X83333 antibody, transducin like enhancer of split 4 antibody, transducin-like enhancer protein 4 antibody, protein groucho-1 antibody, transducin-like enhancer of split 4 antibody, transducin like enhancer of split 4-Z 1 antibody, transducin like enhancer of split 4 S homeolog antibody, TLE4 antibody, LOC706619 antibody, LOC100117159 antibody, LOC100462498 antibody, Tle4 antibody, TLE4Z1 antibody, LOC476317 antibody, tle4.S antibody
    Background

    Synonyms: B lymphocyte gene 1, B lymphocyte gene 1, enhancer of split groucho 4, enhancer of split groucho 4, ESG4, ESG4, KIAA1261, TIM, TIM1, timeless Drosophila homolog, TLE4, transducin-like enhancer of split 4, transducin-like enhancer of split 4, TLE4_HUMAN.

    Background: The Notch signaling pathway controls cellular interactions important for the specification of a variety of fates in both invertebrates and vertebrates. Key players in the Notch pathway are the TLE genes (for transducin-like enhancer of split, also designated ESG for enhancer of split groucho), which are human homologs of the Drosophila groucho gene. Groucho is a transcriptional repressor that plays a key role in neurogenesis, segmentation and sex determination. TLEs associate with chromatin in live cells and specifically with Histone H3, but not with other core histones. Expression of the TLE genes, TLE1, TLE2, TLE3 and TLE4, correlate with immature epithelial cells that are progressing toward a terminally differentiated state, suggesting a role during epithelial differentiation. TLE1, TLE2 and TLE3 have elevated expression in cervical squamous metaplasias and carcinomas, while TLE4 is most highly expressed in the brain, particularly in the caudate nucleus. TLE1 and TLE4 contain SP and WD40 domains, through which TLE1 binds AML1 to inhibit AML1-induced transactivation of the CSF1 receptor. In early stages of cell differentiation, TLE1 is upregulated, and TLE2 and TLE4 are downregulated. In later stages, TLE2 and TLE4 are upregulated, and expression of TLE1 decreases.

    Gene ID
    7091
    Pathways
    WNT Signaling
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