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LAMTOR2 antibody (AA 3-100) (AbBy Fluor® 488)

LAMTOR2 Reactivity: Human IF (cc), IF (p) Host: Rabbit Polyclonal AbBy Fluor® 488
Catalog No. ABIN1695623
  • Target See all LAMTOR2 Antibodies
    LAMTOR2 (Late Endosomal/lysosomal Adaptor, MAPK and mTOR Activator 2 (LAMTOR2))
    Binding Specificity
    • 14
    • 7
    • 6
    • 6
    • 6
    • 1
    • 1
    • 1
    AA 3-100
    Reactivity
    • 36
    • 9
    • 1
    Human
    Host
    • 36
    Rabbit
    Clonality
    • 36
    Polyclonal
    Conjugate
    • 6
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This LAMTOR2 antibody is conjugated to AbBy Fluor® 488
    Application
    • 16
    • 14
    • 12
    • 12
    • 12
    • 6
    • 3
    • 2
    • 2
    Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Predicted Reactivity
    Human,Mouse,Rat,Dog,Cow
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human ROBLD3
    Isotype
    IgG
    Top Product
    Discover our top product LAMTOR2 Primary Antibody
  • Application Notes
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Expiry Date
    12 months
  • Target
    LAMTOR2 (Late Endosomal/lysosomal Adaptor, MAPK and mTOR Activator 2 (LAMTOR2))
    Alternative Name
    Robld3 (LAMTOR2 Products)
    Synonyms
    ENDAP antibody, HSPC003 antibody, MAPBPIP antibody, MAPKSP1AP antibody, ROBLD3 antibody, Ragulator2 antibody, p14 antibody, 2010111E04Rik antibody, AL022628 antibody, Mapbpip antibody, P14 antibody, Rab25 antibody, Robld3 antibody, RGD1562501 antibody, cg5189 antibody, endap antibody, hspc003 antibody, mapbpip antibody, mapbpip-B antibody, mapksp1ap antibody, ragulator2 antibody, robld3 antibody, robld3-b antibody, zgc:100811 antibody, lamtor2 antibody, lamtor2-a antibody, lamtor2-b antibody, mapbpip-A antibody, robld3-a antibody, late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 antibody, late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 S homeolog antibody, late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 L homeolog antibody, LAMTOR2 antibody, Lamtor2 antibody, lamtor2.S antibody, lamtor2 antibody, lamtor2.L antibody
    Background

    Synonyms: ENDAP, Endosomal adaptor protein p14, HSPC003, LAMTOR2, Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2, Late endosomal/lysosomal Mp1 interacting protein, Late endosomal/lysosomal Mp1-interacting protein, LTOR2_HUMAN, MAPBPIP, MAPKSP1 adaptor protein, MAPKSP1AP, Mitogen activated protein binding protein interacting protein, Mitogen-activated protein-binding protein-interacting protein, p14, Ragulator complex protein LAMTOR2, Ragulator2, Roadblock domain containing 3, Roadblock domain containing protein 3, Roadblock domain-containing protein 3, ROBLD 3, RP11 336K24.9.

    Background: MP1 (MEK partner 1) functions as a scaffolding protein in the mitogen activated protein (MAP) kinase signaling pathway. Growth factor induced MAP kinase activation is selectively mediated by the extracellular signal-regulated kinase (ERK) cascade. MAPBPIP (mitogen-activated protein-binding protein-interacting protein), also known as p14 and late endosomal/lysosomal MP1-interacting protein, functions as an adaptor protein augmenting the regulation of the MAP kinase cascade. Partner proteins MAPBPIP and MP1 are structurally almost identical each with a five-stranded -sheet flanked between a two-helix and one-helix layer. MAPBPIP compels the recruitment of MP1 to late endosomes where they form a very stable heterodimeric complex required for ERK activation on endosomes. Knockdown of the individual proteins in the MP1/MAPBPIP complex resulted in decreased expression of the partner proteins which implies greater stability of the heterodimeric complex than either MP1 or MAPBPIP individually. Early research suggests the MP1-MAPBPIP-MEK-1 signaling complex may be critical in the regulation of tissue homeostasis.

    Pathways
    PI3K-Akt Signaling
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