CLP1 antibody (AA 1-100) (AbBy Fluor® 488)

Catalog No. ABIN1695435

This anti-CLP1 antibody is a Rabbit Polyclonal antibody detecting CLP1 in WB, IF (cc) and IF (p). Suitable for Human.

Quick Overview for CLP1 antibody (AA 1-100) (AbBy Fluor® 488) (ABIN1695435)

Target: CLP1 (Cleavage and Polyadenylation Factor I Subunit 1 (CLP1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CLP1 antibody is conjugated to AbBy Fluor® 488

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-CLP1 Antibody (AbBy Fluor® 488)

Binding Specificity: AA 1-100

Predicted Reactivity: Human,Mouse,Rat,Cow,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human HEAB

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for CLP1

Target: CLP1 (Cleavage and Polyadenylation Factor I Subunit 1 (CLP1))

Alternative Name: Heab

Background:

Synonyms: ATP/GTP binding protein, CLP 1, clp1, CLP1 cleavage and polyadenylation factor I subunit homolog, CLP1, cleavage and polyadenylation factor I subunit, homolog S. cerevisiae, CLP1, yeast, homolog of, CLP1_HUMAN, hClp1, Homolog of yeast CFIA subunit Clp1p, Polynucleotide kinase Clp1, Pre mRNA cleavage complex II protein Clp1, Pre-mRNA cleavage complex II protein Clp1.

Background: HEAB is a 425 amino acid nuclear protein that belongs to the Clp1 family. Utilizing magnesium, manganese or nickel as cofactors, HEAB participates in the phosphorylation of the 5'-hydroxyl groups of double- and single- stranded RNA and DNA. HEAB is a member of the tRNA splicing endonuclease complex, in conjunction with TSEN2, TSEN15, TSEN34 and TSEN54, and is also a member of the pre-mRNA cleavage complex II. The gene encoding HEAB maps to human chromosome 11q12.1 and mouse chromosome 2 D, mutations to this gene may lead to a reduced pre-mRNA cleavage activity. HEAB exists as two isoforms due to alternative splicing events.

Gene ID: 10978

Pathways: Ribonucleoprotein Complex Subunit Organization